همراهی رسوب c4d با داده های یموگرافیک در بیماران مبتلا بهIgA نفروپاتی (مطالعه مقدماتی)

نصری, حمید and احمدی, علی and رفیعبان کوپایی, محمد and بشردوست, بهمن and ناصری, پرتو and مبارک, محمود (1393) همراهی رسوب c4d با داده های یموگرافیک در بیماران مبتلا بهIgA نفروپاتی (مطالعه مقدماتی). Journal of nephropathology ــ 4 (1). pp. 19-23. شاپا 2251-8363

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Official URL: http://nephropathol.com/Abstract/JNP_2015011113561...


Association of glomerular C4d deposition with various demographic data in IgA nephropathy patients; a preliminary study

English Abstract

BACKGROUND: IgA nephropathy (IgAN) is the most prevalent primary chronic glomerulopathy worldwide. Thus, it is of vital importance to search for factors aggravating the disease progress, monitor disease activity and predict disease-specific therapy. C4d is a well-known biomarker of the complement cascade with a potential to meet the above needs. OBJECTIVES: The aim of our study was, therefore, to determine whether C4d staining at the time of kidney biopsy had any correlation with the demographic, clinical and biochemical variables in IgAN. PATIENTS AND METHODS: The definition of IgAN requires the presence of diffuse and global IgA deposits which were graded ≥2+ and weak C1q deposition. C4d immunohistochemical staining was conducted retrospectively on 29 renal biopsies of patients with IgAN, which were selected randomly from all biopsies. C4d immunohistochemical staining was performed on 3-μm deparaffinized and rehydrated sections of formaldehyde-fixed, paraffin-embedded renal tissues. RESULTS: Of 29 selected patients, 68% were male. In this study, 54.2±25 percent of glomeruli in all biopsies were positive for C4d. The mean and standard deviation (SD) of serum creatinine and the magnitude of proteinuria were 1.72±1.2 mg/dl and 1582±1214 mg/day, respectively. In this study, we observed statistically significant correlations of percent C4d positivity with the serum creatinine (r=0.61, p=0.0005), magnitude of proteinuria (r=0.72, p=0.0001), the proportion of globally sclerotic glomeruli (r=0.43, p=0.02) and the proportion of tubulointerstitial fibrosis (r=0.54, p=0.0023). CONCLUSIONS: The results from our investigation on C4d positivity in biopsy-proven cases of IgAN are in accord with some of the previous studies. These findings, however, require further validation in larger samples

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :حمید نصری
نویسنده :بهمن بشردوست
نویسنده مسئول :محمود مبارک
Additional Information:Indexing in: PubMed central , DOAJ , Google scholar , Index Copernicus
کلیدواژه ها (انگلیسی):C4d, Complement, Glomerulopathy, IgA nephropathy, Immunohistochemistry
Subjects:QY Clinical Pathology
WJ Urogenital System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:6668
Deposited By: Dr Shahram Habibzadeh
Deposited On:19 Feb 1394 03:32
Last Modified:08 Sep 1396 08:25

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