آلیسین از سیر تشکیل بیوفلیم و فعالیت آنزیم اوره آز پروتئوس میرابلیس را در شرایط آزمایشگاهی مهار می کند

رنجبر امید, مهسا and ارزنلو, محسن and امانی, مجتبی and شکری آل هاشم, سیده خدیجه and امیر مظفری, نور and پیری دوگاهه, هادی (1394) آلیسین از سیر تشکیل بیوفلیم و فعالیت آنزیم اوره آز پروتئوس میرابلیس را در شرایط آزمایشگاهی مهار می کند. FEMS Microbiology Letters ــ 362 (9). pp. 1-9. شاپا 1097-0378

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Allicin from garlic inhibits the biofilm formation and urease activity of Proteus mirabilis in vitro

English Abstract

Several virulence factors contribute to the pathogenesis of Proteus mirabilis. This study determined the inhibitory effects of allicin on urease, hemolysin and biofilm of P. mirabilis ATCC 12453 and its antimicrobial activity against 20 clinical isolates of P. mirabilis. Allicin did not inhibit hemolysin, whereas it did inhibit relative urease activity in both pre-lysed (half-maximum inhibitory concentration, IC50=4.15μg) and intact cells (IC50=21μg) in a concentration-dependent manner. Allicin at sub-minimum inhibitory concentrations (2–32μg/mL) showed no significant effects on the growth ofthe bacteria (P>0.05), but it reduced biofilm development in a concentration-dependent manner (P<0.001). A higher concentration of allicin was needed to inhibit the established biofilms. Using the microdilution technique, the MIC90 and MBC90 values of allicin against P. mirabilis isolates were determined to be 128 and 512μg/mL respectively. The results suggest that allicin could have clinical applications in controlling P. mirabilis infections

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :مهسا رنجبر امید
نویسنده مسئول :محسن ارزنلو
نویسنده :مجتبی امانی
نویسنده :سیده خدیجه شکری آل هاشم
نویسنده :نور امیر مظفری
نویسنده :هادی پیری دوگاهه
Additional Information:Impact factor(2015): 1.858 Indexing in: MEDLINE/ PubMed ,Science Citation Index Expanded , Science Citation Index , Current Contents - Life Sciences , BIOSIS Previews , Google Scholar
کلیدواژه ها (انگلیسی):allicin, Proteus mirabilis, antimicrobial, urease, hemolysin, biofilm
Subjects:QW Microbiology and Immunology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Biophysics
Faculty of Medicine > Department of Basic Sciences > Department of Microbiology
ID Code:6680
Deposited By: Dr Mohsen Arzanlou
Deposited On:27 Feb 1394 05:25
Last Modified:21 Dec 1395 10:22

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