ارزیابی استرس اکسیداتیو و ترشح انسولین در جزایر لانگرهانس جدا شده از موش صحرایی پس از مواجهه با بنزن

بهادر, حاجی and مقبول, فهیم and مصطفی لو, سارا and بعیری, مریم and رحیمی فرد, مهبان and نوایی نیگجه, مونا and عبدالهی, محمد (1394) ارزیابی استرس اکسیداتیو و ترشح انسولین در جزایر لانگرهانس جدا شده از موش صحرایی پس از مواجهه با بنزن. Environmental Toxicology and Pharmacology ــ 39 (3). pp. 1161-1169. شاپا 1382-6689

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Assessment of benzene induced oxidative impairment in rat isolated pancreatic islets and effect on insulin secretion

English Abstract

Benzene (C6H6) is an organic compound used in petrochemicals and numerous other industries. It is abundantly released to our environment as a chemical pollutant causing widespread human exposure. This study mainly focused on benzene induced toxicity on rat pancreatic islets with respect to oxidative damage, insulin secretion and glucokinase (GK) activity. Benzene was dissolved in corn oil and administered orally at doses 200, 400 and 800mg/kg/day, for 4 weeks. In rats, benzene significantly raised the concentration of plasma insulin. Also the effect of benzene on the release of glucose-induced insulin was pronounced in isolated islets. Benzene caused oxidative DNA damage and lipid peroxidation, and also reduced the cell viability and total thiols groups, in the islets of exposed rats. In conclusion, the current study revealed that pancreatic glucose metabolism is susceptible to benzene toxicity and the resultant oxidative stress could lead to functional abnormalities in the pancreas.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :حاجی بهادر
نویسنده :فهیم مقبول
نویسنده :سارا مصطفی لو
نویسنده مسئول :محمد عبدالهی
Additional Information:Impact Factor: 1.862 Abstracting and Indexing : Science Citation Index Expanded BIOSIS , Current Contents/Life Sciences , Science Citation Index , Elsevier BIOBASE , Chemical Abstracts , EMBASE , Environmental Mutagene Information Center , Scopus , EMBiology
Uncontrolled Keywords:بنزن، آلاینده های زیست محیطی، مقاومت به انسولین، استرس اکسیداتیو
کلیدواژه ها (انگلیسی):Benzene, Environmental pollutants, Insulin resistance, Oxidative stress
Subjects:QV pharmacology > QV 600 Toxicology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:6692
Deposited By: Dr Sara Mostafalou
Deposited On:09 Mar 1394 05:07
Last Modified:09 Mar 1394 05:07

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