اثر مفید ورزش منظم بر حافظه طولانی مدت مختل شده در رتهای ماده محروم از خواب

Title

The beneficial effects of regular exercise on long-term memory impairment in sleep deprived female rats

English Abstract

Background and aim: Previous studies showed that exercise can improve long-term memory impairment in sleep deprived male rats. The aim of the present study was to investigate the effects of treadmill exercise on paradoxical sleep deprivation (PSD) -induced impairment in hippocampal dependent long-term memory in female rats. Methods: Intact and ovariectomized female rats were used in the current study. Exercise protocol was 4 weeks treadmill running. Twenty four hour PSD was induced by using multiple platform apparatus after learning phase. Spatial long-term memory was examined by using the Morris Water Maze (MWM) test. Results: Our results indicated that paradoxical sleep deprivation impaired long term memory in the intact and ovariectomized female rats (p<0.05) and treadmill exercise compensated this impairment (p<0.05). Conclusion: In conclusion the results of the current study confirmed the negative effect of PSD on cognitive functions and regular exercise seems to protect rats from these factors, however more investigations need to be done.

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