اثر کافئین بر یادگیری و حافظه فضایی مختل شده توسط محرومیت از خواب در رتهای ماده

اسماعیل پور, خدیجه and شیبانی, وحید and سعادتی, حکیمه and معصومی اردکانی, یاسر (1393) اثر کافئین بر یادگیری و حافظه فضایی مختل شده توسط محرومیت از خواب در رتهای ماده. در: سومین کنگره علوم اعصاب پایه و بالینی, 7-9 آبان 1393, مرکز بین المللی همایشهای رازی - تهران - ایران.

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The effect of caffeine on sleep lose- induced deficit in spatial learning and memory of female rats

English Abstract

Background and aim: Previous studies have shown that caffeine has beneficial effects on cognitive impairment in sleep deprived male rats. Therefore in the present study, we examined the effects of chronic caffeine administration on learning and memory impairments induced by sleep deprivation (SD) in the intact and ovarectomized female rats. Methods: Multiple platform method was used for SD induction. Spatial learning and memory were determined using Morris water maze (MWM) task. Results: Our results indicated that sleep deprivation impaired spatial learning and memory in both OVX and intact female rats (P<0.05). Therefore, caffeine administration improved these impairments. Conclusion: In conclusion, the data showed that caffeine treatment protect against cognitive impairment induced by SD in female rats.

Item Type:Conference or Workshop Item (Speech)
زبان سند : انگلیسی
نویسنده مسئول :خدیجه اسماعیل پور
کلیدواژه ها (انگلیسی):Learning and memory, Sleep deprivation, caffeine, Female rats
Subjects:QT physiology
WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:6730
Deposited By: Dr. Hakimeh Saadati
Deposited On:19 Mar 1394 03:27
Last Modified:19 Mar 1394 03:27

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