title

اثر اخته کردن بر حساسیت موشهای صحرایی نر به اختلالات رفتاری و شکل پذیری سیناپسی ناشی از محرومیت از خواب

حاج علی, وحید and شیبانی, وحید and قزوینی, حامد and قدیری, طاهره and ولی زاده, تکتم and سعادتی, حکیمه and شعبانی, محمد (1394) اثر اخته کردن بر حساسیت موشهای صحرایی نر به اختلالات رفتاری و شکل پذیری سیناپسی ناشی از محرومیت از خواب. Neurobiology of Learning and Memory ــ 123 (Septem). pp. 140-148. شاپا 1074-7427

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Title

Effect of castration on the susceptibility of male rats to the sleep 4 deprivation-induced impairment of behavioral and synaptic plasticity

English Abstract

In both human and animal studies, the effect of sleep deficiency on cognitive performances has mostly been studied during adulthood in males, but very little data exist concerning the effects of poor sleep in gonadal hormones-depleted status, such as aging or gonadectomized (GDX) male animal models. The present study investigated the potential modulatory effects of the endogenous male sex hormones on the 48 h REM sleep deprivation (SD)-induced cognitive and synaptic impairments by comparing the gonadally intact with castrated male rats, a rodent model of androgen-deprived male animals. The multiple platform method was used for inducing REM-SD and spatial performances were evaluated using Morris water maze (MWM) task. Early long-term potentiation (E-LTP) was measured in area CA1 of the hippocampus and PCR and western blotting assays were employed to assess brain derived neurotrophic factor (BDNF) gene and protein expression in the hippocampus. To reveal any influence of sleep loss on stress level, we also evaluated the plasma corticosterone levels of animals. Regardless of reproductive status, REM-SD significantly disrupted short-term memory and LTP, as well as hippocampal BDNF expression. The corticosterone levels were not significantly changed following REM-SD neither in intact nor in GDX male rats. These findings suggest that depletion of male sex steroid hormones by castration does not lead to any heightened sensitivity of male animals to the deleterious effects of 48 h REM-SD on cognitive and synaptic performances.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :وحید حاج علی
نویسنده :وحید شیبانی
نویسنده :حامد قزوینی
نویسنده :طاهره قدیری
نویسنده :تکتم ولی زاده
نویسنده :حکیمه سعادتی
نویسنده :محمد شعبانی
Additional Information:Impact Factor(2014) 3.652 Indexing in: Science Citation Index , Science Citation Index Expanded , Social Sciences Citation Index , Current Contents - Life Sciences , BIOSIS Previews , Scopus
کلیدواژه ها (انگلیسی):Sleep deprivation; Spatial memory; Long-term potentiation; Brain derived neurotropic factor; Gonadectomy --------------------------------------------------------------------------------
Subjects:QT physiology
WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:6738
Deposited By: Dr. Hakimeh Saadati
Deposited On:30 Mar 1394 08:40
Last Modified:14 Oct 1394 08:31

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