سلولهای بنیادی فولیکول مو: تمایز نورونی در آزمایشگاه و در بدن

نجف زاده, نوروز and اسمعیل زاده, بنفشه and داستان, مریم (1394) سلولهای بنیادی فولیکول مو: تمایز نورونی در آزمایشگاه و در بدن. world journal of stem cells ــ 7 (5). pp. 866-872. شاپا 1948-0210


Official URL: http://www.wjgnet.com/1948-0210/abstract/v7/i5/866...


Hair follicle stem cells: In vitro and in vivo neural differentiation

English Abstract

Hair follicle stem cells (HFSCs) normally give rise to keratinocytes, sebocytes, and transient amplifying progenitor cells. Along with the capacity to proliferate rapidly, HFSCs provide the basis for establishing a putative source of stem cells for cell therapy. HFSCs are multipotent stem cells originating from the bulge area. The importance of these cells arises from two important characteristics, distinguishing them from all other adult stem cells. First, they are accessible and proliferate for long periods. Second, they are multipotent, possessing the ability to differentiate into mesodermal and ectodermal cell types. In addition to a developmental capacity in vitro, HFSCs display an ability to form differentiated cells in vivo. During the last two decades, numerous studies have led to the development of an appropriate culture condition for producing various cell lineages from HFSCs. Therefore, these stem cells are considered as a novel source for cell therapy of a broad spectrum of neurodegenerative disorders. This review presents the current status of human, rat, and mouse HFSCs from both the cellular and molecular biology and cell therapy perspectives. The first section of this review highlights the importance of HFSCs and in vitro differentiation, while the final section emphasizes the significance of cell differentiation in vivo.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :نوروز نجف زاده
سایر :بنفشه اسمعیل زاده
سایر :مریم داستان
Additional Information:Indexed in: PubMed/PMC
Uncontrolled Keywords:فولیکول مو، سلول بنیادی، ناحیه بالج، نورون، تمایز
کلیدواژه ها (انگلیسی):Hair follicle; Stem cells; Bulge area; Neuron; Differentiation
Subjects:QS Human Anatomy
WL Nervous system
WR Dermatology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Anatomy
ID Code:6783
Deposited By: Dr Nowruz Najafzadeh
Deposited On:07 Apr 1394 07:55
Last Modified:18 Sep 1399 13:27

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