بیدو, مارینا ، نیاپور, علی ، صالحی, حسین ، دی آمیچی, النا ، جیوبودی, ماتیلده ، ورچلی, الساندرو (1393) درمان ترکیبی با استفاده از پیوند همزمان سلول های بنیادی مزانشیمی و سلول های پیش ساز عصبی به همراه تمرین و محیط نگهداری نقویت شده حرکتی در درمان ضایعات نخاعی مدل موشی. Advances in Stem Cells ــ 2014 . ص.ص.1-22. شاپا 3569-2327
متن کامل
متنی
- نسخه چاپ شده
محدود به فقط پرسنل سامانه 2MB |
آدرس اینترنتی رسمی : http://www.ibimapublishing.com/journals/ASC/asc.ht...
عنوان انگليسی
Combined Treatment by Cotransplantation of Mesenchymal Stem Cells and Neural Progenitors with Exercise and Enriched Environment Housing in Mouse Spinal Cord Injury
خلاصه انگلیسی
Spinal cord injury (SCI) leads to persistent functional impairment due to loss of neurons and glia, and to reduced axonal regeneration following trauma. Therefore SCI is an invalidating pathology, unfortunately without effective treatments. Here, we have tested, in a murine compression SCI model, the effect of exposure to enriched environment (EE) and spontaneous exercise combined to stem cell transplantation, all treatments generally known to exert cell survival and proliferation, synaptogenesis, angiogenesis, and to promote neuroprotection. We report that cotransplantation of neural precursors and mesenchymal stem cells can induce: i) an anatomical recovery in terms of lesion volume reduction and white matter sparing, even though with limited effects on astrogliosis, and ii) locomotor function improvement (as shown by Basso Mouse Scale, foot-fault, hindlimb flexion and sensory tests). These positive effects are only partially boosted by the EE housing and exercise. Interestingly we observed that both stem cell types can mutually influence their survival, proliferation and differentiation, and occasionally undergo cell fusion. We have demonstrated that, among the described approaches, the stem cell use appears the more successful one, and that its combination with EE housing and exercise only generates limited advantages.
نوع سند : | مقاله |
---|---|
زبان سند : | انگلیسی |
نویسنده مسئول : | مارینا بیدو |
ضریب تاثیر و نمایه مجلات: | U.S. National Library of Medicine (NLM Catalog), U.S. National Center for Biotechnology Information (GEO Catalog), Media Finder, Ulrich's Periodicals Directory, JournalSeek, Airiti Library, CNKI Scholar, J-Gate, WorldCat |
کلیدواژه ها (انگلیسی): | Compression injury, stem cell therapy, neurotrophic factors, motor behavior |
موضوعات : | QS آناتومی انسان WL سیستم عصبی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه علوم پایه > بخش علوم تشريح |
کد شناسایی : | 6807 |
ارائه شده توسط : | دکتر علی نیاپور |
ارائه شده در تاریخ : | 04 مرداد 1394 06:34 |
آخرین تغییر : | 10 شهریور 1397 09:56 |
فقط پرسنل کتابخانه صفحه کنترل اسناد