بکارگیري تست HPSAELISA براي اثبات عفونت هلیکوباکترپیلوري در کودکان با درد شکمی راجعه و مقایسه علائم بالینی بین کودکان با و بدون عفونت هلیکو باکتر پیلوري

Title

HPSAELISA Test for Demonstration of Helicobacter Pylori Infection in Childhood Recurrent Abdominal Pain (RAP) and Comparision of Symptoms among Children with and Without Helicobacter Pylori Infection

English Abstract

Background: Recurrent abdominal pain (RAP) is one of the prevalent gastrointestinal problems among children. Stool antigen test as a noninvasive test with high sensitivity are used to evaluate the Helicobacter pylori infection in children with stomachache and then the results of test are compared to children symptoms. Methods: this study in tow phase, first phase as cross sectional then second phase as case-control method was done between elementary school the first phase The schools were chosen through cluster sampling and those children with RAP confirmed by Naish and Apley’s criteria were taken. The number of students examined was 1558. Among this population, 145 student has stomachache. In the second phase of study, 145 healthy children from the same area who had no clinical manifestations of RAP recruited as the control group. Both groups underwent stool antigen tests using Hp SA ELISA. The obtained data were analyzed by SPSS (version16), using chi-square and t-tests. Results: Stool antigen test evaluation in children with and without RAP showed that 85 person (58.6%) of children with RAP has positive test result. RAP characters survey showed that in children with positive Helicobacter pylori test, 61 person (42%) have 3-6 month duration of symptoms and 14 person (9.7%) 6-12 month. In the negative Helicobacter pylori test group,40 person (27.5%) has 3-6 month duration of symptoms and 6 persons (4.2%) 6-12 month, that there was no statistically significant difference between them. In the same way children was compared to location of stomachache, concomitant gastrointestinal symptoms, pain in hunger, abdominal pain subsiding after defecation, visiting physician after having abdominal pain and having interruption in daily activities due to abdominal pain, and there was no statistically significant difference between them. Discussion: As for study results in comparison of case and control group for Helicobacter pylori infection percent and no significant differences and conceder to high diagnostic power of used test, there are other reasons for RAP that it is necessary to evaluate them in other studies.students in different districts of Ardabil city. In

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