تاثیر ویتامین ث بر روی سیستم اندوکرین و استرس اکسیداتیو در پاسخ به فعالیت

بابایی, پروین and رحمانی نیا, فرهاد and نخستین روحی, بابک and بهلولی, شهاب (1388) تاثیر ویتامین ث بر روی سیستم اندوکرین و استرس اکسیداتیو در پاسخ به فعالیت. Journal of Clinical and Diagnostic Research ــ 3 (4). pp. 1627-1632. شاپا 0973-709X

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The effect of VC on immunoendocrine and oxidative stress responses to exercise

English Abstract

The depression of the immune system function that is typically observed after strenuous exercise is believed to be possibly mediated by stress hormones, cytokines and oxidative stress. The aim of this study was to measure immunoendocrine and oxidative stress responses after the ingestion of two different doses of Vitamin C (VC) supplementation. Twenty-four healthy untrained males participated in a 30-min exercise at 75%Vo2max. Immediately pre-exercise, the participants received either of the following regimens: placebo, 500 mg and 1000 mg of VC. Blood samples were obtained prior to ingestion, immediately after ingestion, 2hrs after ingestion and also 2hrs and 24hrs after exercise. Vitamin C used in doses of 500 mg and 1000 mg could significantly increase the plasma VC concentration and antioxidant capacity in both vitamin receiving groups. The increase in total antioxidant capacity (TAC) followed a significant decrease in post-exercise oxidative stress markers like malondialdehyde (MDA) (P<0.05). Markers of inflammation (total leukocytes, neutrophils and IL-6), muscle damage, creatine kinase (CK) and stress hormone (cortisol) were found to significantly increase in response to the exercise (P<0.05), but VC supplementation failed to decrease these factors significantly. The results suggest that acute supplementation with moderate and high doses of VC might prevent exercise-induced lipid peroxidation but not inflammatory markers.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :پروین بابایی
نویسنده :شهاب بهلولی
Additional Information:Indexed : 2- Embase & EMbiology , SCOPUS 3-Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts (ISA), Popline (reproductive health literature),
Uncontrolled Keywords:اسکوربات ، هورمون استرس ، سیتوکین ، استرس اکسیداتیو
کلیدواژه ها (انگلیسی):Ascorbate ; stress hormone ; cytokine ; oxidative stress
Subjects:QV pharmacology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Pharmacology
ID Code:686
Deposited By: Dr Shahab Bohlooli
Deposited On:25 Oct 1388 16:06
Last Modified:15 Nov 1391 13:50

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