اثر جبرانی ورزش منظم بر اختلال حافظه طولانی مدت در موشهای بزرگ آزمایشگاهی ماده محروم از خواب

سالاری, مریم and شیبانی, وحید and سعادتی, حکیمه and پور رحیمی, علی محمد and خاکساری, محمد and اسماعیل پور, خدیجه and خدامرادی, مهدی (1394) اثر جبرانی ورزش منظم بر اختلال حافظه طولانی مدت در موشهای بزرگ آزمایشگاهی ماده محروم از خواب. Behavioural Processes ــ (119). pp. 50-57. شاپا 6357-0376

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The compensatory effect of regular exercise on long-term memory impairment in sleep deprived female rats

English Abstract

Previous studies have been shown that exercise can improve short-term spatial learning, memory and synaptic plasticity impairments in sleep deprived female rats. The aim of the present study was to investigate the effects of treadmill exercise on sleep deprivation (SD) induced impairment in hippocampal dependent long-term memory in female rats. Intact and ovariectomized female rats were used in the current study. Exercise protocol was 4 weeks treadmill running. Twenty four hour SD was induced by using multiple platform apparatus after learning phase. Spatial learning and long-term memory was examined by using the Morris Water Maze (MWM) test. Our results indicated that sleep deprivation impaired long term memory in the intact and ovariectomized female rats, regardless of reproductive status (p < 0.05) and treadmill exercise compensated this impairment (p < 0.05). In conclusion the results of the current study confirmed the negative effect of SD on cognitive functions and regular exercise seems to protect rats from these factors, however more investigations need to be done.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :مریم سالاری
نویسنده مسئول :وحید شیبانی
نویسنده مسئول :حکیمه سعادتی
نویسنده :علی محمد پور رحیمی
نویسنده :محمد خاکساری
نویسنده :خدیجه اسماعیل پور
نویسنده :مهدی خدامرادی
Additional Information:Impact Factor: (2014) 1.567 Indexed in: ISI, PubMed/Medline, Scopus
کلیدواژه ها (انگلیسی):Sleep deprivation; Regular exercise; Long-term memory; Morris water maze; Female rats
Subjects:WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:6879
Deposited By: Dr. Hakimeh Saadati
Deposited On:08 Jun 1394 06:01
Last Modified:18 Sep 1399 13:05

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