بهبود اختلال یادگیری و حافظه فضایی موشهای بزرگ آزمایشگاهی ماده محروم از خواب توسط کافئین

اسماعیل پور, خدیجه and شیبانی, وحید and سعادتی, حکیمه (1394) بهبود اختلال یادگیری و حافظه فضایی موشهای بزرگ آزمایشگاهی ماده محروم از خواب توسط کافئین. Physiology and Pharmacology ــ 19 (2). pp. 121-129. شاپا 1735-0581


Official URL: http://www.phypha.ir/ppj/index.php?&slct_pg_id=10&...


Caffeine improved spatial learning and memory deficit in sleep deprived female rat

English Abstract

Previous studies have shown that caffeine has beneficial effects on cognitive impairment in sleep deprived male rats. Therefore in the present study, we examined the effects of chronic caffeine administration on learning and memory impairments induced by sleep deprivation (SD) in the intact and ovarectomized (OVX) female rats. Two sets of animals including intact and OVX were randomly recruited into the following subgroups: control, SD, wide platform (Sham platform), caffeine, and caffeine plus SD. Multiple platform method was used for SD induction. Spatial learning and memory were determined using Morris water maze (MWM) task. Throughout behavioral investigation, significant learning impairment was observed in sleep-deprived OVX rats compared to the intact and the other OVX groups (P<0.05). Short term memory impairment was observed in both sleep-deprived OVX and intact groups (P<0.05). 4weeks caffeine administration improved these impairments. Based on these findings we propose that sleep deprivation impaired cognitive function whereas caffeine treatment reversed these impairments.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :خدیجه اسماعیل پور
نویسنده مسئول :وحید شیبانی
نویسنده :حکیمه سعادتی
Additional Information:Indexed in: Scopus, EMBASE, Index Copernicus , SID, DOAJ, IRANMEDEX, Magiran
کلیدواژه ها (انگلیسی):Sleep deprivation, caffeine, Morris water maze, Female rats
Subjects:WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:6901
Deposited By: Dr. Hakimeh Saadati
Deposited On:12 Jul 1394 05:41
Last Modified:18 Sep 1399 13:07

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