فارماکوکینتیک مبودیپین، آنتاگونیست جدید کلسیم، متعاقب تجویز تک دوز وریدی یا خوراکی در موش آزمایشگاهی

بهلولی, شهاب and کیهانفر, فریبرز and محمودیان, مسعود (1383) فارماکوکینتیک مبودیپین، آنتاگونیست جدید کلسیم، متعاقب تجویز تک دوز وریدی یا خوراکی در موش آزمایشگاهی. Biopharmaceutics and Drug Disposition ــ 25 (4). pp. 187-191. شاپا 0142-2782

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Pharmacokinetics of Mebudipine, a new calcium antagonist, following single intravenous and oral administrations in rats

English Abstract

The pharmacokinetics of a new calcium antagonist, mebudipine, was studied after a single intravenous (0.5mg/kg) and oral (10mg/kg) administration to rats. After intravenous dosing, the plasma concentration of mebudipine declined biexponentially with a terminal half-life of 2.84 h. The blood clearance was 1.67 1/h/kg and the volume of distribution at steady state was found to be 6.26 1/kg. After oral dosing (10 mg/kg), the Cmax of mebudipine was 25.9.79 ng/ml. The oral bioavailability was low (< 2%) suggesting a marked first-pass effect. The distribution of mebudipine into some tissues such as brain, heart, liver and kidney following intravenous administration (0.5mg/kg) was studied and a rapid distribution of mebudipine into these tissues was found. It was concluded that brain, heart, liver and kidney are in the same compartment as plasma (central). Copyright © 2004 John Wiley & Sons, Ltd.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :شهاب بهلولی
Additional Information:Online ISSN: 1099-081X
Uncontrolled Keywords:مبودیپین ، فارماکوکینتیک ، موش بزرگ ، HPLC
کلیدواژه ها (انگلیسی):mebudipine , pharmacokinetics , rat, hplc
Subjects:QV pharmacology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Pharmacology
ID Code:691
Deposited By: Dr Shahab Bohlooli
Deposited On:25 Oct 1388 16:06
Last Modified:24 Nov 1391 11:35

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