title

استفاده از ترکیب سینرجیستی دو ماده تسریع کننده نفوذ داروی پوستی کلاژن در فرآورده های دارویی و آرایشی بهداشتی

شکری, نرگس and اکبری جور, حمید (1393) استفاده از ترکیب سینرجیستی دو ماده تسریع کننده نفوذ داروی پوستی کلاژن در فرآورده های دارویی و آرایشی بهداشتی. Journal of pharmaceutical research ــ 14 (1). pp. 1-6. شاپا 7200-0973

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Title

Using a synergistic combination of two enhancers for dermal delivery of collagen in pharmaceutical and cosmetic products

English Abstract

Objectives: Dermal delivery is an excellent route of drug administration. In this study, Zinc Oxide nanoparticles (ZnO-NPs) and 6 solvents were used as enhancers to promote dermal permeation of collagen. Methods: Formulations contained collagen, solvent and ZnO-NPs. Permeation of collagen was determined by an ex-vivo (animal skin) method. Results: Using sunflower oil, olive oil, coconut oil, liquid paraffin, Dimethyl sulfoxide or Tetrahydrofuran, lead to permeation of 46, 47, 60, 241, 56 and 35 mg collagen, respectively. Addition of 200 mg ZnO-NPs, resulted in permeation of 68, 61, 72, 286, 63 and 47 mg collagen, respectively. Using 300 or 400 mg ZnO-NPs and liquid paraffin, lead to permeation of 299 and 286 mg collagen, respectively. Conclusion: Using the solvents or ZnO-NPs enhanced the permeation of collagen. The enhancement was more when a solvent and ZnO-NPs were used simultaneously. Among them, combination of liquid paraffin and ZnO-NPs, showed a synergistic enhancing effect leading to the maximum permeation observed in the study. This was explained with the completely different enhancing mechanisms of liquid paraffin and ZnO-NPs. Therefore, the study suggests using liquid paraffin and ZnO-NPs or other combinations of enhancers having distinct mechanisms, to prominently improve the permeation of collagen.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :نرگس شکری
نویسنده :حمید اکبری جور
Additional Information:indexed in: index copernicus, Chemical abstract service
Uncontrolled Keywords:کلاژن، نانوذرات زینک اکساید، حلال های آلی، نفوذ پوستی
کلیدواژه ها (انگلیسی):Collagen; ZnO nanoparticles; Organic solvents, Skin permeation
Subjects:QV pharmacology > QV 704 Pharmaceutics
Divisions:School of Pharmacy > Department of Pharmaceutics
ID Code:6934
Deposited By: Dr Narges Shokri
Deposited On:09 Jul 1394 05:54
Last Modified:01 Oct 1394 09:05

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  • استفاده از ترکیب سینرجیستی دو ماده تسریع کننده نفوذ داروی پوستی کلاژن در فرآورده های دارویی و آرایشی بهداشتی. (deposited 09 Jul 1394 05:54) [Currently Displayed]

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