title

اثر سیلی بوم مارینوم در درمان و پیشگیری از هپاتوتوکسیتی

فتحی, افشین and امانی, فیروز (1394) اثر سیلی بوم مارینوم در درمان و پیشگیری از هپاتوتوکسیتی. در: challenges in pediatric hematology& oncology, sep ,16-18 2015, Tehran, Iran.

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Title

The effect of Silybum marianum in treatment and prevention of hepatotoxicity in patients undergoing induction therapy for acute lymphoblastic leukemia

English Abstract

Background and objective: Using Hepatotoxic drugs in induction phase in patients with acute Lymphoblastic Leukemia increases liver enzymes, therefore, maintenance therapy with other hepatotoxic medications seem to have some difficulties. Recently, effects of treatment with Silymarin in monitoring serum levels of liver enzymes in ALL patients were considered. This study aimed to investigate the effects of Silymarin in treatment and prevention of liver toxicity in patients undergoing induction phase. Methods: In this clinical trial, patients diagnosed with Acute Lymphoblastic Leukemia who underwent induction therapy were enrolled, randomly treated with Silymarin and placebo for 28 days. Laboratory tests were done in patients on days 0, 28 and 56 and results were recorded and analyzed by SPSS.19. P<0.05 was considered significant. Results: The mean age of patients in case group was 4.8 ± 2.4 and in placebo group was 5.8 ± 3.3 years. The mean serum ALT and AST levels in our two groups were not significantly different on day 0 and day 28, but showed a significant difference in day 56 which ALT and AST levels decreased significantly in case group compare control. Conclusion: The use of Silymarin in induction phase of ALL treatment significantly reduces liver enzymes and side effects of chemotherapy.

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده اول :افشین فتحی
نویسنده :فیروز امانی
کلیدواژه ها (انگلیسی):Acute lymphoblast leukemia, Hepatotoxicity, Silymarin
Subjects:WS Pediatrics
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
ID Code:6979
Deposited By: Dr Firouz Amani
Deposited On:20 Jul 1394 06:01
Last Modified:07 Sep 1394 11:45

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