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اثر ریشه کنی هلیکوباکتر پیلوری در بیماران ایرانی مبتلا به سوء هاضمه عملکردی: یک تحقیق کنترل شده با پلاسبو تصادفی آینده نگر

یزدانبد, عباس ، ملکی, نصراله ، سلیمیان, سینا ، حبیب زاده, شهرام ، هوشيار, افشين ، نوروزوند, مریم (1394) اثر ریشه کنی هلیکوباکتر پیلوری در بیماران ایرانی مبتلا به سوء هاضمه عملکردی: یک تحقیق کنترل شده با پلاسبو تصادفی آینده نگر. Archives of Medical Science ــ 11 (5). ص.ص.964-969. شاپا 1922-1734

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عنوان انگليسی

Effect of Helicobacter pylori eradication in Iranian patients with functional dyspepsia: a prospective, randomized, placebo-controlled trial

خلاصه انگلیسی

Introduction: Whether patients with functional dyspepsia (FD) should receive Helicobacter pylori (H. pylori) eradication therapy remains controversial. The objective of this trial was to evaluate the effect of H. pylori eradication therapy on dyspeptic symptoms of patients with FD. Material and methods: A prospective, randomized, placebo-controlled trial of H. pylori eradication for FD was conducted. A total of 720 FD patients diagnosed by Rome III criteria were consecutively enrolled. We randomly assigned 186 H. pylori infected patients with FD to receive quadruple therapy for 14 days and 173 such patients to receive identical-appearing placebos. Severity of abdominal symptoms was assessed with the Glasgow Dyspepsia Severity Score (GDSS), and eradication of H. pylori by 13C-urea breath test was evaluated during one year. Results: The rate of eradication of H. pylori infection was 87.1% in the treatment group and 2.9% in the placebo group at 6 weeks (p = 0.001). The mean GDSS at 12 months was 4.9 ±2.8 in the treatment group, as compared to 5.2 ±3.4 in the placebo group (p = 0.064). The scores in both groups were lower than those at baseline. According to the intention-to-treat analysis, at 12 months, there was no significant difference between groups in the rate of successful treatment (48.6% in the treatment group and 51.2% in the placebo group; p = 0.84). There was no significant difference in mean symptom scores between the two treatment groups at any point during follow-up. Conclusions: The results of our study provide no evidence that H. pylori eradication leads to relief of symptoms 12 months after treatment, and there is a need for further studies.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :عباس یزدانبد
نویسنده مسئول :نصراله ملکی
نویسنده :سینا سلیمیان
نویسنده :شهرام حبیب زاده
نویسنده :افشين هوشيار
نویسنده :مریم نوروزوند
ضریب تاثیر و نمایه مجلات:Impact Factor (2014): 2.03 Indexed in: ISI, PubMed/PMC, Scopus, Chemical Abstracts, Embase, Index Copernicus, DOAJ, CAb Abstracts,
کلیدواژه ها (انگلیسی):functional dyspepsia, helicobacter pylori, eradication
موضوعات :WI سیستم گوارشی
بخش های دانشگاهی :دانشكده پزشكي > گروه داخلی ، قلب ، عفونی
کد شناسایی :7020
ارائه شده توسط : دکتر نصراله ملکی
ارائه شده در تاریخ :28 مهر 1394 06:14
آخرین تغییر :06 شهریور 1398 16:03

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