ترکیب اثر آنتی اکسیدانی اریتروپویتین و ملاتونین بر آسیب ایسکیمی-رپرفیوژن کلیه موش صحرایی

احمدی اصل, ناصر and بنایی, شکوفه and علی همتی, علیرضا (1392) ترکیب اثر آنتی اکسیدانی اریتروپویتین و ملاتونین بر آسیب ایسکیمی-رپرفیوژن کلیه موش صحرایی. Iranian Journal of Basic Medical Sciences ــ 16 (12). pp. 1209-1216. شاپا 3866-2008

[img] Text - Published Version
محدود به Repository staff only


Official URL: http://ijbms.mums.ac.ir


Combination Antioxidant Effect of Erythropoietin and Melatonin on Renal Ischemia-Reperfusion Injury in Rats

English Abstract

Objective(s): Renal ischemia reperfusion (IR) contributes to the development of acute renal failure (ARF). Oxygen free radicals are considered to be principal components involved in the pathophysiological tissue alterations observed during renal IR. The purpose of this study was to investigate the effect of co-administration of melatonin (MEL) and erythropoietin (EPO), potent antioxidant and anti-inflammatory agents, on IR-induced renal injury in rats. Materials and Methods: Wistar albino rats were unilaterally nephrectomized and subjected to 45 min of renal pedicle occlusion followed by 24 hr reperfusion. MEL (10 mg/kg, IP) and EPO (5000 U/kg, IP) were administered prior to ischemia. After 24 hr reperfusion, following decapitation, renal samples were taken for the determination of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) levels and histological evaluation. The level of urea was measured in serum samples. Results: Ischemia reperfusion significantly increased urea, and MDA levels, and decreased CAT and SOD activities. Histopathological findings of the IR group confirmed that there was renal impairment in the tubular epithelium. Treatment with EPO and MEL markedly decreased urea level and increased SOD and GPx activities. Conclusion: Treatment with EPO and MEL had a beneficial effect on renal IR injury. These results may show that the co-administration of MEL and EPO cannot exert more beneficial effects than either agent alone.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :ناصر احمدی اصل
نویسنده مسئول :شکوفه بنایی
نویسنده :علیرضا علی همتی
Additional Information:Impact Factor (2015) 1.22 Indexed in: ISI, Pubmed, DOAJ, ISC, ***Original Article
کلیدواژه ها (انگلیسی):Antioxidant, Erythropoietin, Ischemia Reperfusion Injury, Kidney, Lipid Peroxidation, Melatonin
Subjects:QT physiology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:7099
Deposited By: Dr shokofeh banaei kivi
Deposited On:26 Apr 1395 11:08
Last Modified:26 Apr 1395 11:08

Repository Staff Only: item control page

Document Downloads

More statistics for this item...