نقش جدید میکروآرناها در آسیب کلیه ناشی از ایسکیمی-رپرفیوژن

بنایی, شکوفه (1394) نقش جدید میکروآرناها در آسیب کلیه ناشی از ایسکیمی-رپرفیوژن. Renal Failure ــ 37 (7). pp. 1073-1079. شاپا 0886-022X

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Official URL: http://www.tandfonline.com/toc/irnf20/current


Novel role of microRNAs in renal ischemia reperfusion injury

English Abstract

Renal ischemia reperfusion injury (IRI) contributes to the development of acute kidney injury (AKI). Several processes are involved in the development of renal IRI with the generation of reactive oxygen species, inflammation and apoptosis. MicroRNAs (miRNAs) are endogenous, small and noncoding RNAs that repress gene expression of target mRNA in animals posttranscriptionally. miRNA-mediated gene repression is a major modulatory mechanism to regulate fundamental cellular processes such as the cell cycle, proliferation, growth, and apoptosis, which in turn have pivotal influences on pathophysiological outcomes. Recent studies have revealed the pathogenic roles played by miRNAs in many renal diseases, such as IRI, AKI and renal carcinoma. In addition, the majority of miRNAs identified appear to be differentially expressed, probably to quell the injury response by modulating inflammation, apoptosis and proliferation and may point us toward new pathways that can be targeted to regulate or prevent renal IRI. They may represent novel diagnostic biomarkers of renal IR injury.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :شکوفه بنایی
Additional Information:Impact Factor (2014) 0.944 Indexed in: ISI, Pubmed/Medline, Index Medicus, Scopus
کلیدواژه ها (انگلیسی):Acute kidney injury, erythropoietin, ischemia reperfusion injury, miRNAs, melatonin, reactive oxygen species
Subjects:QT physiology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:7102
Deposited By: Dr shokofeh banaei kivi
Deposited On:12 Dec 1394 12:55
Last Modified:22 May 1399 07:28

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