title

بررسی اثر سیتوتوکسیک تعدادی از مشتقات 1و4-دی هیدروپیریدینی در سلول های سرطانی انسانی

رزاقی اصل, نیما and میری, رامین and فیروزی, امیدرضا (1395) بررسی اثر سیتوتوکسیک تعدادی از مشتقات 1و4-دی هیدروپیریدینی در سلول های سرطانی انسانی. Iranian Journal of Pharmaceutical Research ــ 15 (3). pp. 413-420. شاپا 1735-0328

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Title

Assessment of the Cytotoxic Effect of a Series of 1,4-Dihydropyridine Derivatives Against Human Cancer Cells

English Abstract

Cancer is a leading cause of death worldwide. Despite the availability of several chemotherapeutic drugs, there is still a great need for more efficient agents for a better management of cancer. In this contribution, a series of 11 1,4-dihydropyridines (1,4-DHPs) (4a, 4b and 7a-i) were synthesized and evaluated for their cytotoxic effect against MCF-7, LS180 and MOLT-4 cancer cell lines using MTT assay. Synthesized 2,6-dimethyl-3,5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1,4-dihydropyridines exhibited different potencies ranging from weak to good cytotoxic activities, while no activity could be recorded for 1,4-bis(2,6-dimethyl-3,5-dialkyloxylcarbonyl,4-dihydropyridine-4-yl) benzene compounds (4a and 4b). Tested DHP derivatives were more potent against MOLT-4 cells, when compared to LS180 and MCF-7 cells. Compounds 7d (IC50 = 28.5 ± 3.5 µM), 7a (IC50 = 29.7 ± 4.7 µM) and 7a (IC50 = 17.4 ± 2.0 µM) were the most potent derivatives against MCF-7, LS180 and MOLT-4 cells, respectively. It appeared that the introduction of N-thiazolyl carbamoyl group at the C3 and C5 positions of DHP ring enhanced the cytotoxic potential of these derivatives (compounds 7a-e). The findings of this study suggest that some of the thiazole substituted 1,4-DHPs may be candidates for further modifications towards the discovery of potent anticancer agents.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :نیما رزاقی اصل
نویسنده :رامین میری
نویسنده مسئول :امیدرضا فیروزی
Additional Information:Impact Factor (2016): 1.507 ISI, Pubmed,Scopus, Chemical Abstracts , Embase, Index Copernicus, EMRO, ISC, Scientific Information Database (SID), Open Gate Journal, Google Scholar, IranMedex, IPA, DOAJ,
کلیدواژه ها (انگلیسی):Synthesis, Dihydropyridine, Anticancer activity, MTT assay
Subjects:QV pharmacology > QV 744 Medicinal Chemistry
QV pharmacology
Divisions:School of Pharmacy > Department of Medicinal Chemistry
ID Code:7107
Deposited By: Mrs sepideh Dashti
Deposited On:02 Nov 1395 04:21
Last Modified:12 Dec 1396 08:09

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