ارتباط پلی مورفیسم ناحیه انتهایی vacA و 3'هلیکوباکتر پیلوری با سرطان معده

بختی, سیده زهرا and لطیفی نوید, سعید and محمدی, شیوا and ظهری, صابر and بختی, فاطمه سادات and فیضی, فریده and یزدانبد, عباس and سیاوشی, فریده (1394) ارتباط پلی مورفیسم ناحیه انتهایی vacA و 3'هلیکوباکتر پیلوری با سرطان معده. Helicobacter ــ online . شاپا 5378-1523

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/hel.122...


Relevance of Helicobacter pylori vacA 3ʹ-end Region Polymorphism to Gastric Cancer

English Abstract

Background Helicobacter pylori vacA genotypes play an important role in the pathogenesis of severe gastrointestinal disease. Materials and Methods We identified a novel polymorphic site in the 3ʹ-end region of H. pylori vacA gene, denoted by c1/-c2 (c1: with deletion of 15 bp), and examined associations of this and the previous four sites as well as cagA status with gastroduodenal diseases, in a total of 217 Iranian H. pylori isolates. Histopathologic evaluations were performed and patients with gastric cancer (GC) were further classified based on the anatomic site of tumor, including cardia and noncardia GC, and the histopathologic type of tumor, including intestinal- and diffuse-type GC. Results The vacA m1, i1, d1, c1, and cagA genotypes were significantly associated with an increased risk of GC, the odds ratio (95% confidence interval) was 4.29 (2.03–9.08), 6.11 (2.63–14.19), 3.18 (1.49–6.76), 15.13 (5.86–39.01), and 2.59 (1.09–6.12), respectively. The vacA c1 genotype had an increased age- and sex-adjusted risk for GC by the multiple logistic regression analysis; the OR was 38.32 (95% CI, 6.60–222.29). This association was independent of and larger than the associations of the m-, i-, and d-type of vacA or cagA status with GC. No significant correlation was found between s1, whether independently or in combination, and the risk of GC or peptic ulcer disease (PUD). The vacA i1 and cagA genotypes were linked to an increased risk of PUD; the OR (95% CI) was 2.80 (1.45–5.40) and 2.62 (1.23–5.61), respectively. The presence of both the vacA i1 and cagA genotypes further increased the risk of PUD; the OR was 5.20 (95% CI, 1.92–14.03). Conclusion The H. pylori vacA c1 genotype might therefore be one of the strongest risk predictors of GC in male patients aged ≥55 in Iran.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :سیده زهرا بختی
نویسنده مسئول :سعید لطیفی نوید
نویسنده :شیوا محمدی
نویسنده :صابر ظهری
نویسنده :فاطمه سادات بختی
نویسنده :فریده فیضی
نویسنده :عباس یزدانبد
نویسنده :فریده سیاوشی
Additional Information:Impact Factor(2014) 4.106 Indexed in: ISI, Pubmed/Medline/Index Medicus,Scopus, Abstracts in Anthropology, Biological Abstracts,BIOSIS Previews , CAB Abstracts, CSA Biological Sciences Database, Protozoological Abstracts, Environment Index, Index Veterinarius, Current Contents: Clinical Medicine, CSA Microbiology Databases
کلیدواژه ها (انگلیسی):H. pylori ; cagA ; gastric cancer; genotyping; vacA 3ʹ-end region
Subjects:QW Microbiology and Immunology
WI Digestive System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:7207
Deposited By: Dr Nasrollah Maleki
Deposited On:14 Oct 1394 06:21
Last Modified:18 Jul 1395 12:09

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