درمان اسفنجی گرانباری آهن توسط ماکروفاژهایی با افزایش بیان هپسیدین

محمدزاده وردین, محمد and پناهپور, حمداله and گل محمدی, محمد قاسم and سقا, محسن (1395) درمان اسفنجی گرانباری آهن توسط ماکروفاژهایی با افزایش بیان هپسیدین. Macrophage ــ 3 . pp. 1-3. شاپا 2378-136X


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Spongious therapy of iron overload with hipcidin overexpressed macrophages

English Abstract

Iron overload is a major cause of morbidity and mortality in some diseases such as beta thalassemia. Conventional therapies with phlebotomy and iron chelating agents have shown no profound effect on iron excessive disease. Moreover, hepcidin as an iron transport inhibitor can absorb more iron than normal level following overexpression in macrophages. For this purpose, We hypothised that repeat transplantation of manipulated macrophages and their replacement, can remove the excess iron and decrease iron toxicity, a process that is called, spongious therapy.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :محمد محمدزاده وردین
نویسنده :حمداله پناهپور
نویسنده :محمد قاسم گل محمدی
نویسنده مسئول :محسن سقا
Additional Information:Indexed in: Google Scholar
کلیدواژه ها (انگلیسی):Iron Overload, Thalassemia, Iron Chelating Agents, Macrophages, Transplantation, Hepcidin
Subjects:QS Human Anatomy
QT physiology
WH Hemic and Lymphatic System
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Anatomy
ID Code:7229
Deposited By: Dr Mohammad Mohammadzadeh
Deposited On:14 Oct 1394 08:13
Last Modified:18 Sep 1399 11:55

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