عبدالهی, محمد and مصطفی لو, سارا (1393) ضد افسردگی های سه حلقه ای. در: Encyclopedia of Toxicology. Tricyclic Antidepressants, 4 . Elsevier, Amsterdam, pp. 838-845. شابک 3-386454-12-0-978
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Official URL: http://www.sciencedirect.com/science/article/pii/B...
Title
Tricyclic Antidepressants
English Abstract
Tricyclic antidepressants (TCAs), one of the most common causes of death from poisoning, are used to treat major depression and other medical disorders. They have a lipophilic structure and high potential for bioconcentration. TCAs are rapidly absorbed after ingestion and have a large volume of distribution, which can delay their elimination for up to 10 days. They act as a reuptake inhibitor of catecholamines, including serotonin and norepinephrine, but they have also anticholinergic, antihistaminic, alpha blockade, and quinidine-like effects. Cardiotoxicity is the main adverse effect of TCAs on overdose, and sodium bicarbonate is used to treat intoxication.
| Item Type: | Book Section |
|---|---|
| زبان سند : | انگلیسی |
| نویسنده مسئول : | محمد عبدالهی |
| نویسنده : | سارا مصطفی لو |
| کلیدواژه ها (انگلیسی): | Anticholinergic; Antidepressant; Antihistamine; Anxiety; Bipolar disorder; Major depression; Norepinephrine; Obsessive compulsive disorder; Serotonin |
| Subjects: | QV pharmacology > QV 600 Toxicology QV pharmacology |
| Divisions: | School of Pharmacy > Department of Toxicology |
| ID Code: | 7273 |
| Deposited By: | Dr Sara Mostafalou |
| Deposited On: | 21 Nov 1394 09:49 |
| Last Modified: | 21 Nov 1394 09:56 |
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