ضد افسردگی های سه حلقه ای

عبدالهی, محمد and مصطفی لو, سارا (1393) ضد افسردگی های سه حلقه ای. در: Encyclopedia of Toxicology. Tricyclic Antidepressants, 4 . Elsevier, Amsterdam, pp. 838-845. شابک 3-386454-12-0-978

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Tricyclic Antidepressants

English Abstract

Tricyclic antidepressants (TCAs), one of the most common causes of death from poisoning, are used to treat major depression and other medical disorders. They have a lipophilic structure and high potential for bioconcentration. TCAs are rapidly absorbed after ingestion and have a large volume of distribution, which can delay their elimination for up to 10 days. They act as a reuptake inhibitor of catecholamines, including serotonin and norepinephrine, but they have also anticholinergic, antihistaminic, alpha blockade, and quinidine-like effects. Cardiotoxicity is the main adverse effect of TCAs on overdose, and sodium bicarbonate is used to treat intoxication.

Item Type:Book Section
زبان سند : انگلیسی
نویسنده مسئول :محمد عبدالهی
نویسنده :سارا مصطفی لو
کلیدواژه ها (انگلیسی):Anticholinergic; Antidepressant; Antihistamine; Anxiety; Bipolar disorder; Major depression; Norepinephrine; Obsessive compulsive disorder; Serotonin
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:7273
Deposited By: Dr Sara Mostafalou
Deposited On:21 Nov 1394 09:49
Last Modified:21 Nov 1394 09:56

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