بیان بالای ماشین بیوژنز microRNA: دورشا، دی جی سی آر 8، و دایسر در بیماران مبتلا به ام اس

جعفری, ناصر and صادقی, حسن and محمودی, داود and شیرزاد, زهره and علی بیکی, فاطمه and بهلولی, شهاب and پیری دوگاهه, هادی (1393) بیان بالای ماشین بیوژنز microRNA: دورشا، دی جی سی آر 8، و دایسر در بیماران مبتلا به ام اس. Journal of clinical neuroscience ــ 22 (1). pp. 200-203. شاپا 1532-2653

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Overexpression of microRNA biogenesis machinery: Drosha, DGCR8 and Dicer in multiple sclerosis patients

English Abstract

We aimed to evaluate the expression of the major components of microRNA biogenesis machinery including Drosha, Dicer and DiGeorge syndrome critical region gene 8 (DGCR8) in multiple sclerosis (MS) patients. The expression levels of these components in relapsing remitting multiple sclerosis (RRMS) patients were significantly up-regulated in comparison to healthy controls. DGCR8 was up-regulated 4.9 times in RRMS patients versus healthy controls, and Drosha was up-regulated 3.58 times. Additionally, the expression level of Dicer was 2.11 times higher in RRMS patients than the healthy controls. In conclusion, our results suggest that overexpression of Drosha, Dicer and DGCR8 may contribute to the pathogenesis of MS. Further investigation may introduce microRNA biogenesis machinery as MS markers and therapeutic targets.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :ناصر جعفری
نویسنده :حسن صادقی
نویسنده :داود محمودی
نویسنده :زهره شیرزاد
نویسنده :فاطمه علی بیکی
نویسنده :شهاب بهلولی
نویسنده مسئول :هادی پیری دوگاهه
Additional Information:Impact Factor(2014)1.378 Indexed in: ISI, Pubmed/ Medline/ Index medicus, Scopus, Biobase
Uncontrolled Keywords:دایسر، دورشا، بیان ژنی، MicroRNA، ام اس
کلیدواژه ها (انگلیسی):Dicer; DGCR8; Drosha; Gene expression; MicroRNA machinery; Multiple sclerosis
Subjects:QV pharmacology
Divisions:School of Pharmacy > Department of Pharmacology
ID Code:7287
Deposited By: Dr Shahab Bohlooli
Deposited On:09 Oct 1394 07:25
Last Modified:15 Oct 1398 10:55

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