تاثیر مثبت ورزش بر افزایش تعداد سلولهای بنیادی عصبی از طریق هورمون رشد و تشدید پاسخ ترمیمی در سیستم عصبی موشهای مسن

بلکمور, دانیل and گل محمدی, محمد قاسم and لارج, بیترس and واترز, م-جی and ریتز, رادنی لی (1388) تاثیر مثبت ورزش بر افزایش تعداد سلولهای بنیادی عصبی از طریق هورمون رشد و تشدید پاسخ ترمیمی در سیستم عصبی موشهای مسن. Stem Cells ــ 27 (8). pp. 2044-2052. شاپا 1066-5099

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Exercise Increases Neural Stem Cell Number in a GH-Dependent Manner, Augmenting the Regenerative Response in Aged Mice

English Abstract

The exercise-induced enhancement of learning and memory, and its ability to slow age-related cognitive decline in humans led us to investigate whether running stimulates periventricular (PVR) neural stem cells (NSCs) in aging mice, thereby augmenting the regenerative capacity of the brain. To establish a benchmark of normal aging on endogenous NSCs, we harvested the PVR from serial vibratome sections through the lateral ventricles of juvenile (6-8 weeks), 6, 12, 18, and 24-month-old mice, culturing the cells in the neural colony forming cell assay. A significant decline in NSC frequency was apparent by 6-months (~40%) ultimately resulting in a ~90% reduction by 24-months. Concurrent with this decline was a progressive loss in regenerative capacity, as reflected by an incomplete repopulation of neurosphere-forming cells following gamma cell irradiation-induced depletion of the PVR. However voluntary exercise (i.e. 21 days of running) significantly increased NSC frequency in mice

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :دانیل بلکمور
نویسنده :محمد قاسم گل محمدی
نویسنده مسئول :رادنی لی ریتز
Additional Information:Impact Factor: 7.741 Indexed:1- ISI,MEDLINE/PubMed 2-Scopus-Index medicus
کلیدواژه ها (انگلیسی):neural stem cell , aging , bromodeoxyuridine , running wheel , neurosphere
Subjects:WL Nervous system
QS Human Anatomy
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Anatomy
ID Code:731
Deposited By: Dr Mohammad Gasem Golmohammani
Deposited On:27 Oct 1388 06:40
Last Modified:07 Jul 1393 06:21

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