title

مروری بر بیماریهای اندوکرین در ارتباط با سموم محیطی و مکانیسم های در گیر

مقبول, فهیم and مصطفی لو, سارا and بهادر, حاجی and عبدالهی, محمد (1394) مروری بر بیماریهای اندوکرین در ارتباط با سموم محیطی و مکانیسم های در گیر. Life sciences ــ 145 . pp. 265-273. شاپا 3205-0024

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Title

Review of endocrine disorders associated with environmental toxicants and possible involved mechanisms

English Abstract

Endocrine disrupting chemicals (EDC) are released into environment from different sources. They are mainly used in packaging industries, pesticides and food constituents. Clinical evidence, experimental models, and epidemiological studies suggest that EDC have major risks for human by targeting different organs and systems in the body. Multiple mechanisms are involved in targeting the normal system, through estrogen receptors, nuclear receptors and steroidal receptors activation. In this review, different methods by which xenobiotics stimulate signaling pathways and genetic mutation or DNA methylation have been discussed. These methods help to understand the results of xenobiotic action on the endocrine system. Endocrine disturbances in the human body result in breast cancer, ovarian problems, thyroid eruptions, testicular carcinoma, Alzheimer disease, schizophrenia, nerve damage and obesity. EDC characterize a wide class of compounds such as organochlorinated pesticides, industrial wastes, plastics and plasticizers, fuels and numerous other elements that exist in the environment or are in high use during daily life. The interactions and mechanism of toxicity in relation to human general health problems, especially endocrine disturbances with particular reference to reproductive problems, diabetes, and breast, testicular and ovarian cancers should be deeply investigated. There should also be a focus on public awareness of these EDC risks and their use in routine life. Therefore, the aim of this review is to summarize all evidence regarding different physiological disruptions in the body and possible involved mechanisms, to prove the association between endocrine disruptions and human diseases.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :فهیم مقبول
نویسنده :سارا مصطفی لو
نویسنده :حاجی بهادر
نویسنده مسئول :محمد عبدالهی
Additional Information:Impact Factor (2014) 2.702 Indexed in: ISI, Scopus, BIOSIS, Biological and Agricultural Index, Elsevier BIOBASE, Current Contents, EMBASE, Energy Data Base, Energy Research Abstracts, Nutrition Abstracts, EMBiology
کلیدواژه ها (انگلیسی):Endocrine disruptors, Environment, Neoplasm, Estrogens, Bisphenol A, Aneuploidy, Steroids, Systematic review
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:7428
Deposited By: Dr Sara Mostafalou
Deposited On:11 Dec 1394 11:26
Last Modified:11 Dec 1394 11:26

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