بهلولی, شهاب and محمدی, پرهام سعداله and مأذنی, محمد and رضایی, نریمان (1394) مطالعه اثر ضد سرطانی عصاره گیاه آگروستماجیتاگو بر روی مدل حیوانی سرطان معده و اندازه گیری مارکرهای نترین 1 و سایتوکراتین های M30 و M65. Masters (پایان نامه) دانشگاه علوم پزشکی اردبیل.
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Title
Anti Cancer Effect of Agrostemma githago Extract on Animal Model of Gastric Cancer and Evaluation the Level of Netrin 1 and Cytokeratin18 ( m30 & m65 )
English Abstract
Back ground and objectives Gastric cancer is one of the most common cancer in the world. Because in human case of cancer is so complicated, it has been tried to induce this cancer in rats and has tried to examine the anti cancer effects of A.githago on rat model. Methods 80 rats were randomized into seven groups as follows: Co rats were fed citrate buffer and normal saline. Cco were fed MNU and saturated Nacl orally via intra gastric tube. Ccot were fed MNU and saturated Nacl. Cis Rats were given MNU and sNacl. 0.1 mg A.githago Rats were given MNU and sNacl and rats were injected every 4 days with A.githago extraction. 1 mg A.githago Rats were given MNU and sNacl rats were injected every 4 days with A.githago extraction. Control A.githago the rats of this group just treated with A.githago extract with the dosage of 1 mg/kg. nanoliposomal extract of A.githago Rats were given MNU and sNacl and rats were treated with nanoliposomal extract of A.githago. Results 0.1 mg/kg A.githago’s group: cancer incidence in this group was 100%. 1 mg/kg A.githago’ s group: cancer incidence in this group was 100%. Cancer control group: cancer incidence in this group was 100% .A.githago’s control group: cancer incidence in this group was 10%. A.githago’s treatment group: cancer incidence in this group was 75%. Cancer control treatment: cancer incidence in this group was 100. Cisplatin group: cancer incidence in this group was 80% . Conclusions In general (pre-treatment and treatment groups), the worst dosage was 1 mg/kg that intensified the cancer and the best dosage was 0.1 mg/kg ( better than cisplatin and nanoliposomal form A.githago’s extract ) that attenuated cancer a little but did not meet our expectations of improved cancer.
| Item Type: | Thesis (Masters) |
|---|---|
| زبان سند : | انگلیسی |
| استاد راهنما : | شهاب بهلولی |
| استاد راهنما : | پرهام سعداله محمدی |
| استاد مشاور : | محمد مأذنی |
| دانشجو : | نریمان رضایی |
| Additional Information: | شماره پایان نامه : 15 ، پایان نامه کارشناسی ارشد بیوشیمی بالینی |
| Uncontrolled Keywords: | سرطان معده ، سرطان سلول سنگفرشی ، آگروستماجیتاگو ، ان متیل ان نیتروزاوره آ ، نمک اشباع |
| کلیدواژه ها (انگلیسی): | Gastric cancer- Squamous cell carcinoma- Agrostemma githago- N-methyl-N-nitrosurea- Saturated Nacl. |
| Subjects: | QV pharmacology > QV 767 Traditional Pharmaceutics QU Biochemistry WI Digestive System |
| Divisions: | Faculty of Medicine > research unit > sumitted thesis Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry School of Pharmacy > Department of Traditional Pharmaceutics |
| ID Code: | 7459 |
| Deposited By: | Mr farhad khodaei |
| Deposited On: | 13 Dec 1394 07:24 |
| Last Modified: | 02 Apr 1399 09:45 |
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