محرومیت از خواب و اختلالات شناختی در موشهای بزرگ آزمایشگاهی ماده:اثرات مفید ورزش

Title

Sleep Deprivation and Cognitive Impairments in Female Rats: The Beneficial Effects of Exercise

English Abstract

Inadequate sleep is a common problem in modern societies. Physical exercise has Been suggested to attenuate the cognitive impairments induced by sleep deprivation (SD) in male rats. Female rats are more vulnerable to the deleterious effects of SD on cognitive functions. The objective of the current study was to investigate the effects of physical exercise on learning and memory, LTP and the levels of BDNF mRNA and protein in the hippocampus of female rats following SD. Intact and ovariectomiezed (OVX) female Wistar rats were used in the present study. The exercise protocol was four weeks treadmill running and the multiple platform method was applied to induce 72 h SD. The cognitive functions were evaluated by using Morris water maze (MWM) and field potential recording in the CA1 area of the hippocampus. Quantitative RT-PCR and immunoblot analysis were used to evaluate the level of hippocampus BDNF mRNA and protein, respectively. Learning and short term memory of sleep-deprived OVX rats were impaired compared to the intact and the OVX groups in MWM (p<0.05).Field potential recording data Indicated that the induction and maintenance phase of E-LTP impaired in the sleep deprived animals compared to the other groups. Physical exercise alleviated the SD-induced behavioral performances and E-LTP impairments in both intact and OVX groups (p<0.05). Also, protein and mRNA expression of BDNF was significantly (p<0.05) decreased after SD in OVX rats in compared with other groups. Furthermore, sleep deprived OVX rats under exercise conditions had asignificant (p< 0.05) up-regulation Of the mRNA and BDNF protein. In conclusion, the regular exercise can improve the cognitive functions deficits in sleep-deprived female rats and exert a protective effect against hippocampus-related impairments induced by SD probably by inducing BDNF expression.

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