تهیه پلیمر چاپ شده مولکولی جدید به روش سل-ژل برای استخراج ویتامین D3

کیا, سولماز and فضیلتی, محمد and صلواتی, حسین and بهلولی, شهاب (1395) تهیه پلیمر چاپ شده مولکولی جدید به روش سل-ژل برای استخراج ویتامین D3. RSC Advances ــ 6 (38). pp. 31906-31914. شاپا 2069-2046

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Official URL: http://pubs.rsc.org/en/journals/journalissues/ra


Preparation of a novel molecularly imprinted polymer by the sol–gel process for solid phase extraction of vitamin D3

English Abstract

A novel molecularly imprinted polymer (MIP) as an artificial receptor for vitamin D3 is prepared and used. A sol–gel process is used to prepare the hybrid MIP. For the organic part (gel) of the MIP, methacrylic acid (MAA), ethylene glycol dimethacrylate (EGDMA) and benzoylperoxide are used as functional monomer, cross-liker and initializer, respectively. As the inorganic part (sol) of the MIP, tetraethyl orthosilicate (TEOS) is used. The main parameters affecting the synthesis of the organic–inorganic hybrid MIP are investigated and optimized. The imprinting efficiency of the MIP is evaluated by comparing the adsorbed amount of vitamin D3 by the MIP with that by the related non-imprinted polymer (NIP). Betamethasone, dexamethasone, 17-beta-stradiol and 25-hydroxy vitamin D3 were chosen to study the selectivity of the MIP. This study revealed that the MIP possesses a remarkable affinity for vitamin D3. A limit of detection of 1 ng mL−1 has been achieved. The linear range and relative standard deviation (RSD%) were 1–10 000 ng mL−1 and 4 (n = 3), respectively. The hybrid MIP provides fast, selective and convenient separation of vitamin D3 from aqueous samples.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :سولماز کیا
نویسنده :محمد فضیلتی
نویسنده :حسین صلواتی
نویسنده مسئول :شهاب بهلولی
Additional Information:Impact Factor (2014) 3.840 Indexed in: ISI, Scopus
کلیدواژه ها (انگلیسی):Vitamin D3, SOl-gel, MIP, Extraction
Subjects:QV pharmacology > QV 778 Pharmaceutical Nanotechnology
QU Biochemistry
QV pharmacology
Divisions:School of Pharmacy > Department of Pharmacology
ID Code:7514
Deposited By: Dr Shahab Bohlooli
Deposited On:15 Jan 1395 08:14
Last Modified:15 Jan 1395 08:14

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