انتقال پروتئین تیمیدیلات کیناز بواسطه میکرووزیکولهای اختصاصی تومور پوشیده با آنتی بادی

محمدزاده وردین, محمد and پناهپور, حمداله and گل محمدی, محمد قاسم and سقا, محسن (1395) انتقال پروتئین تیمیدیلات کیناز بواسطه میکرووزیکولهای اختصاصی تومور پوشیده با آنتی بادی. Critical Reviews in Eukaryotic Gene Expression ــ 26 (1). pp. 11-17. شاپا 1045-4403

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Protein Delivery of Thymidylate Kinase Mediated by Tumor-Specific Antibody-Precoated Microvesicles

English Abstract

Molecular targeted therapy is an important, novel approach in the treatment of cancer because it interferes with certain molecules involved in carcinogenesis and tumor growth. Examples include monoclonal antibodies, microvesicles, and suicide genes. Several studies have focused on targeted therapies in prostate cancer, which is a serious cause of cancer death in men. We hypothesize that antibody-coated microvesicles can deliver thymidylate kinase, a suicide protein, to prostate cancer cells, potentiating them to death following azidothymidine (AZT) treatment.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :محمد محمدزاده وردین
نویسنده :حمداله پناهپور
نویسنده :محمد قاسم گل محمدی
نویسنده مسئول :محسن سقا
Additional Information:Impact Factor (2016) 1.559 Indexed in: ISI, Scopus, PubMed/Medline, Embase
کلیدواژه ها (انگلیسی):monoclonal antibody, microvesicles, suicide gene therapy, molecular targeted therapy
Subjects:QS Human Anatomy
QU Biochemistry
QW Microbiology and Immunology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Anatomy
ID Code:7542
Deposited By: Dr Mohammad Mohammadzadeh
Deposited On:25 Jan 1395 06:21
Last Modified:22 Jul 1400 09:46

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