کوورستین آسیب ایسکمی-ریپرفیوژن عصب محیطی را از طریق دخالت در مسیر NF-kappa B کاهش می دهد(2016)

غلامی, محمد رضا and خانی پور خیاط, زهرا and عنبری, خاطره and عبیداوی, ضیا and ورزی, علی محمد and بیگی بروجنی, ماندانا and علیپور, محسن and نیاپور, علی and محمد غراوی, آنه (1394) کوورستین آسیب ایسکمی-ریپرفیوژن عصب محیطی را از طریق دخالت در مسیر NF-kappa B کاهش می دهد(2016). Anatomical Science International ــ 92 (3). pp. 303-307. شاپا 1447-6959

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Official URL: https://link.springer.com/article/10.1007%2Fs12565...


Quercetin ameliorates peripheral nerve ischemia–reperfusion injury through the NF-kappa B pathway

English Abstract

This study aimed to investigate the protective effect of quercetin against ischemia–reperfusion (IR) injury induced in the sciatic nerve of the rat. Quercetin (20 mg/ kg) was given during ischemia just before reperfusion. Four groups of rats (Q?IR3, Q?IR7, Q?IR14, and Q?IR28) received 3, 7, 14, and 28 days of reperfusion, respectively, after the intraperitoneal injection of quercetin. After reperfusion, a behavioral test was performed and the sciatic functional index was calculated. Each sciatic nerve was stained to check for edema and ischemic fiber degeneration. Immunohistochemical staining was performed to detect TNF-alpha and NF-kappa B, and TUNEL staining was carried out to detect apoptosis. The Q?IR3, Q?IR7, and Q?IR14 groups showed significantly increased behavioral scores and ameliorated sciatic functional index values compared to IR-injured rats that received vehicle alone during ischemia and then the same period of reperfusion. The Q?IR3, Q?IR7, Q?IR14, and Q?IR28 groups presented significant ischemic fiber degeneration (IFD), TNF-alpha expression, and apoptosis as compared with the IR-injured and perfused rats that did not receive quercetin. The Q?IR3, Q?IR7, and Q?IR28 groups also exhibited significantly decreased NF-kappa B expression (p\0.001, p = 0.001, p = 0.026) as compared with the IR-injured rats that were perfused but did not receive quercetin. These results imply that quercetin may be beneficial in the treatment of sciatic IR injury because of its antiapoptotic and antiinflammatory effects and its ability to decrease the expression of NF-kappa B.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :محمد رضا غلامی
نویسنده :علی نیاپور
نویسنده مسئول :آنه محمد غراوی
Additional Information:Impact Factor (2014) 0.827 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus
کلیدواژه ها (انگلیسی):Quercetin, Ischemia–reperfusion, Sciatic, functional index, Ischemic fiber degeneration, TNF-alpha, NF-kappa B, Apoptosis
Subjects:QS Human Anatomy
WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Anatomy
ID Code:7563
Deposited By: Dr Ali Niapour
Deposited On:04 Feb 1395 07:40
Last Modified:31 Jun 1400 09:04

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