title

سمیت کوپریزون به عنوان یک عامل شلاته کننده مس بر روی میتوکندری های ایزوله شده از مغز موش سوری: یک تائیدی برای دملینه شدن و اختلالات رفتاری بعدی

فیضی, مهرداد and سلیمی, احمد and صیدی, عنایت اله and ناصر زاده, پروانه and کوهنورد, مهدی and رحیمی, آتنا and پوراحمد, جلال (1395) سمیت کوپریزون به عنوان یک عامل شلاته کننده مس بر روی میتوکندری های ایزوله شده از مغز موش سوری: یک تائیدی برای دملینه شدن و اختلالات رفتاری بعدی. Toxicology Mechanisms and Methods ــ 26 (4). pp. 276-283. شاپا 5616-1537

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Title

Toxicity of cuprizone a Cu2+ chelating agent on isolated mouse brain mitochondria: a justification for demyelination and subsequent behavioral dysfunction

English Abstract

Multiple Sclerosis (MS) is a complex disease with an unknown etiology and no effective cure, despite decades of extensive research that led to the development of several partially effective treatments. In this study we aimed to investigate brain mitochondrial dysfunction in demyelination induced by cuprizone in mice. Cuprizone was used for induction of demyelination in mice through a diet containing 0.2% w/w cuprizone for 5 weeks. Behavioral tests for proving of MS was performed and then mitochondria from brain of animals were isolated and afterwards parameters of mitochondrial dysfunction examined. Results of mitochondrial dysfunction parameters such as mitochondrial swelling, production ROS, collapse of the membrane potential showed that isolated mitochondria from cuprizone treated mice have been damaged compared to those of untreated control mice. It is likely that demyelination induced mitochondrial damage led to increased mitochondrial ROS formation and progression of oxidative damages in neurons. It is suggested that cuprizone which is a Cu+2 chelating agent causes impairment of electron transport chain (complex IV) and antioxidant system (SOD) in mitochondria leading to decreased ATP production and increased ROS formation.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :مهرداد فیضی
نویسنده :احمد سلیمی
نویسنده مسئول :جلال پوراحمد
Additional Information:Impact Factor (2014) 1.517 Indexed in: ISI, Pubmed/Medline/Index Medicus, BIOBASE, Biological Abstracts, BIOSIS, EMBASE, EMBIOLOGY, Environment Complete, *RESEARCH ARTICLE
کلیدواژه ها (انگلیسی):Animal model; cuprizone; demyelination; mitochondrial dysfunction
Subjects:QV pharmacology > QV 600 Toxicology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:7570
Deposited By: دکتر احمد سلیمی
Deposited On:04 Feb 1395 07:03
Last Modified:09 May 1396 08:09

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