بررسي دقت تشخيصي وجود آنتي ژن هليكوباكترپيلوري در مدفوع براي تعيين ابتلا به عفونت هليكوباكترپيلوري

Title

Evaluation Study of Helicobacter Pylori Stool Exam Antigen Test in the Diagnosis of Helicobacter Pylori Infection

English Abstract

Background: There are several tests for the detection of H. pylori infection which can be classified as invasive and non-invasive methods. The invasive tests are normally expensive which need endoscopic procedure. It is also not available everywhere, Therefore, there is a need for a quick, inexpensive and reliable non-invasive test to detect H. pylori. This study aimed to evaluate the enzyme immunoassay for the detection of H. pylori antigen in stool in the Ardabil population. Results of tests were compared with gold standard: histology and RUT. Methodology: 60 patients who had been referred to bras clinic by gastroenterologists due to dyspepsia were recruited. The subjects underwent endoscopic examination and twcbiopsies were taken from antrum, the first specimen was used for RUT and the second was used for histology. Meanwhile, a questionnaire was administered and a stool sample were taken and sent for HpSA (Helicobacter pylori Stool Antigen test). Results: If two tests of histology and RUT were positive, patients were considered as H. pylori positive. Thirty patients were positive for H. pylori and equal numbers were negative using gold standard. HpSA was positive in 29 of 30 and negative in 28 of 30. The sensitivity and specificity of the HpSAwere 96.6% and 93.3% respectively. The positive and negative predictive values were 93.5% and 96.5% respectively.

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