آلاینده های آلی ماندگار و ارتباط با بیماریهای متابولیک در زمینه مقاومت به انسولین

مصطفی لو, سارا (1395) آلاینده های آلی ماندگار و ارتباط با بیماریهای متابولیک در زمینه مقاومت به انسولین. در: Reviews of Environmental Contamination and Toxicology. Springer, New York, pp. 69-89.

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Official URL: http://link.springer.com/bookseries/398


Persistent Organic Pollutants and Concern Over the Link with Insulin Resistance Related Metabolic Diseases

English Abstract

Persistent organic pollutants (POPs) are mostly halogenated compounds tending to persist in the environment, enter into the food chain, and accumulate in fat mass of mammals due to their high lipophilicity. They include some organochlorine pesticides, polychlorinated biphenyls, brominated flame retardants and polycyclic aromatic hydrocarbons. Some of these chemicals were widely used in the past so that their residues can be detected in the human body, though their usage has been banned for years. POPs have been shown to perturb the health of biological systems in different ways evidenced by carcinogenicity and disrupting effects on endocrine, immune, and reproductive systems. There are many epidemiologic and experimental studies on the association of exposure to POPs with insulin resistance and related metabolic disorders like obesity, diabetes, and metabolic syndrome. Inflammation as a known mechanism accompanying insulin resistance has also been shown to arise in insulin target tissues exposed to POPs. This review addresses the breast milk concentration of POPs in different regions of the world, synthesizes the current information on the association of POPs with insulin resistance related metabolic disorders, and discusses the inflammation as an involved mechanism. Considering high prevalence of insulin resistance related metabolic diseases and their relation with POPs, much need is felt regarding international and regional programs to not only limit their production and usage but eliminate these persistent pollutants from the environment.

Item Type:Book Section
زبان سند : انگلیسی
نویسنده مسئول :سارا مصطفی لو
Additional Information:Impact Factor (2015) 2.446 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus
کلیدواژه ها (انگلیسی):persistent organic pollutant, insulin resistance
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:7613
Deposited By: Dr Sara Mostafalou
Deposited On:31 Jun 1395 06:45
Last Modified:31 Jun 1395 06:45

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