بررسی هیستوپاتولوژیکی اثر اسید گلیسریزیک به عنوان یک رادیوپروتکتور در مقابل فیبروز ریوی ناشی ار تشعشع

رفاهی, سهیلا and مینائی, باقر and حدادی, غلامحسن and خوئی, سمیده and بختیاریان, اعظم and پورعیسی, مسعود and تکاور, عباس (1395) بررسی هیستوپاتولوژیکی اثر اسید گلیسریزیک به عنوان یک رادیوپروتکتور در مقابل فیبروز ریوی ناشی ار تشعشع. Iranian Journal of Radiology ــ 13 (2). pp. 1-6. شاپا 1065-1735


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Histopathological Evaluation of the Effectiveness of Glycyrrhizic Acid as a Radioprotector Against the Development of Radiation-Induced Lung Fibrosis

English Abstract

Background: Radiotherapy of the thorax often causes lung inflammation leading to fibrosis. Objectives: The aim of this study was to investigate whether the use of glycyrrhizic acid (GLA) could improve the development of lung fibrosis in irradiated animals. Materials and Methods: Wistar rats were divided into four groups. Group A rats received thoracic irradiation. Rats in group B received GLA and irradiation. Group C received GLA and no irradiation. Group D received no GLA and irradiation. GLA was administered at a dose of 4 mg/kg body weight using an intraperitoneal injection one hour before thoracic irradiation. Radiation therapy was delivered on a Cobalt-60 unit using a single fraction of 16 Gy. The animals were sacrificed at 32 weeks following thoracic irradiation. The lungs were dissected and blind histopathological evaluation was performed. Results: Histopathologically, a decrease (statistically not significant) in the thickening of alveolar or bronchial wall, formation of fibrous bands, and superimposed collagen were noted in the animals in group B as compared to the animals in group A. Conclusion: In this experimental study, administration of GLA one hour before thoracic irradiation may be a protective agent against radiation-induced fibrosis in animals and this model could be used in future studies.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :سهیلا رفاهی
نویسنده مسئول :عباس تکاور
Additional Information:Impact Factor (2015) 0/438 Indexed in: ISI, Pubmed, Scopus, CINAHL, EBSCO, Embase, DOAJ, WHO-EMRO Index Medicus, Index Copernicus, Google Scholar, ISC, SID, IranMedex, MagIran
کلیدواژه ها (انگلیسی):: Lung fibrosis, Radioprotector, Glycyrrhizic Acid, Histopathology
Subjects:QY Clinical Pathology
WF Respiratory System
WN Radiology . Diagnostic Imaging
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Medical Physics
ID Code:7630
Deposited By: Dr Soheila Refahi
Deposited On:03 May 1395 11:24
Last Modified:15 Oct 1398 13:59

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