رفاهی, سهیلا ، مینائی, باقر ، حدادی, غلامحسن ، خوئی, سمیده ، بختیاریان, اعظم ، پورعیسی, مسعود ، تکاور, عباس (1395) بررسی هیستوپاتولوژیکی اثر اسید گلیسریزیک به عنوان یک رادیوپروتکتور در مقابل فیبروز ریوی ناشی ار تشعشع. Iranian Journal of Radiology ــ 13 (2). ص.ص.1-6. شاپا 1065-1735
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عنوان انگليسی
Histopathological Evaluation of the Effectiveness of Glycyrrhizic Acid as a Radioprotector Against the Development of Radiation-Induced Lung Fibrosis
خلاصه انگلیسی
Background: Radiotherapy of the thorax often causes lung inflammation leading to fibrosis. Objectives: The aim of this study was to investigate whether the use of glycyrrhizic acid (GLA) could improve the development of lung fibrosis in irradiated animals. Materials and Methods: Wistar rats were divided into four groups. Group A rats received thoracic irradiation. Rats in group B received GLA and irradiation. Group C received GLA and no irradiation. Group D received no GLA and irradiation. GLA was administered at a dose of 4 mg/kg body weight using an intraperitoneal injection one hour before thoracic irradiation. Radiation therapy was delivered on a Cobalt-60 unit using a single fraction of 16 Gy. The animals were sacrificed at 32 weeks following thoracic irradiation. The lungs were dissected and blind histopathological evaluation was performed. Results: Histopathologically, a decrease (statistically not significant) in the thickening of alveolar or bronchial wall, formation of fibrous bands, and superimposed collagen were noted in the animals in group B as compared to the animals in group A. Conclusion: In this experimental study, administration of GLA one hour before thoracic irradiation may be a protective agent against radiation-induced fibrosis in animals and this model could be used in future studies.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | سهیلا رفاهی |
نویسنده مسئول : | عباس تکاور |
ضریب تاثیر و نمایه مجلات: | Impact Factor (2015) 0/438 Indexed in: ISI, Pubmed, Scopus, CINAHL, EBSCO, Embase, DOAJ, WHO-EMRO Index Medicus, Index Copernicus, Google Scholar, ISC, SID, IranMedex, MagIran |
کلیدواژه ها (انگلیسی): | : Lung fibrosis, Radioprotector, Glycyrrhizic Acid, Histopathology |
موضوعات : | QY آسیب شناسی بالینی WF سیستم تنفسی WN پرتو شناسی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه علوم پایه > بخش فیزیک پزشکی |
کد شناسایی : | 7630 |
ارائه شده توسط : | دکتر سهیلا رفاهی |
ارائه شده در تاریخ : | 03 مرداد 1395 11:24 |
آخرین تغییر : | 15 دی 1398 13:59 |
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