تاثیر داروی سیلی مارینوم در درمان و پیشگیری از هیپوتوتوکسیتی در بیماران ALL

فتحی, افشین and امانی, فیروز and روح زنده, ژاله (1395) تاثیر داروی سیلی مارینوم در درمان و پیشگیری از هیپوتوتوکسیتی در بیماران ALL. Pediatric Dimensions ــ 1 (3). pp. 78-80. شاپا 2397-950X


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Effect of silybum marianum in treatment and prevention of hepatotoxicity in patients undergoing reinduction therapy for acute lymphoblastic leukemia (ALL)

English Abstract

Using hepatotoxic drugs in induction phase for ALL patients increases liver enzymes and deal to some difficulties. So, treatment with herbal medicine such as Silymarin in monitoring serum levels of liver enzymes in ALL patients is effective. In a clinical trial study, we selected randomly 30 all patients and divided in two groups. One group treated with Silymarin and another group takes placebo for 56 days. Laboratory tests were done in patients on days 0, 28 and 56. The mean serum ALT and AST levels in two groups were similar in days 0 and 28, but in day 56 a significant decrease was seen in Silymarin group compared to placebo. Results showed that, the use of Silymarin in induction phase of ALL treatment significantly reduces liver enzymes and side effects of chemotherapy and be effective in prevention of hepatotoxicity in ALL patients.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :افشین فتحی
نویسنده مسئول :فیروز امانی
نویسنده :ژاله روح زنده
کلیدواژه ها (انگلیسی):acute lymphoblastic leukemia, hepatotoxicity, silymarin
Subjects:QV pharmacology
WS Pediatrics
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
Faculty of Medicine > Department of Basic Sciences > Department of Vital Statistics
ID Code:7753
Deposited By: Dr Firouz Amani
Deposited On:25 May 1395 05:23
Last Modified:02 Jun 1398 14:02

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