اثر 5- آمینوسالیسیلیک اسید بر آسیب ناشی از ایسکمی- رپرفیوژن کلیه در موشهای صحرایی

Title

The effect of 5‑aminosalicylic acid on renal ischemia‑reperfusion injury in rats

English Abstract

Objectives: Ischemia‑reperfusion (IR) contributes to the development acute renal failure. Oxygen free radicals are involved in the pathophysiology of IR injury (IRI). This study was designed to investigate the effects of 5‑aminosalicylic acid (5‑ASA), which is known antioxidant agent, in IR‑induced renal injury in rats. Materials and Methods: Male Wistar albino rats were unilaterally nephrectomized and subjected to 45 min of renal pedicle occlusion followed by 24 h of reperfusion. 5‑ASA (300 mg/kg, i.p) was administered prior to ischemia. After 24 h reperfusion, urine and blood samples were collected for the determination of creatinine (Cr) and nitric oxide (NO) levels, and renal samples were taken for the histological evaluation. Results: Treatment with 5‑ASA significantly decreased serum Cr and NO levels, also significantly increased urinary Cr level and decreased histopathological changes induced by IR. Conclusion: Treatment with 5‑ASA had a beneficial effect on renal IRI. These results may indicate that 5‑ASA exerts nephroprotective effects in renal IRI.

Document Downloads