مقایسه اثرات حفاظتی اریتروپویتین و ملاتونین بر آسیب ناشی از ایسکمی- رپرفیوژن کلیه

بنایی, شکوفه and احمدی اصل, ناصر and علی همتی, علیرضا (1395) مقایسه اثرات حفاظتی اریتروپویتین و ملاتونین بر آسیب ناشی از ایسکمی- رپرفیوژن کلیه. Trauma Monthly ــ 21 (3). pp. 1-5. شاپا 7464-2251

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Comparison of the Protective Effects of Erythropoietin and Melatonin on Renal Ischemia-Reperfusion Injury

English Abstract

Background: Renal ischemia-reperfusion (IR) contributes to the development of acute renal failure (ARF). Oxygen free radicals are considered to be the principal components involved in the pathophysiological tissue alterations observed during renal IR. Objectives: In this study, we compared the effects of melatonin (MEL) and erythropoietin (EPO), both known antioxidant and antiinflammatory agents, on IR-induced renal injury in rats. Materials and Methods: Wistar albino rats were unilaterally nephrectomized and then subjected to 45 minutes of renal pedicle occlusion followed by 24 hours of reperfusion. MEL (10 mg/kg, i.p) and EPO (5000 U/kg, i.p) were administered prior to the onset of ischemia. After 24 hours of reperfusion and following decapitation, blood samples were collected for the determination of the hemoglobin (Hb) and hematocrit (Hct) levels. Additionally, renal samples were taken for histological evaluation. Results: Ischemia-reperfusion significantly decreased the observed Hb and Hct values. The histopathological findings in the IR group confirmed that there was an increase in the hyaline cast and thickening of the Bowman capsule basement membrane. Treatment with EPO or MEL significantly increased the Hb and Hct values. In the MEL + IR group, the histopathological changes were lower than those found in the EPO + IR group. Conclusions: Treatment with EPO and MEL had a beneficial effect on renal IR injury. The results may also indicate that MEL protects against morphological damage better than EPO in renal IR injury.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :شکوفه بنایی
نویسنده :ناصر احمدی اصل
نویسنده :علیرضا علی همتی
Additional Information:Indexed in: Pubmed, Scopus, ESCI, Embase, DOAJ, Index Copernicus, Google Scholar, ISC, SID, IranMedex
کلیدواژه ها (انگلیسی):Melatonin, Erythropoietin, Ischemia Reperfusion Injury, Kidney
Subjects:QT physiology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:7795
Deposited By: Dr shokofeh banaei kivi
Deposited On:07 Jun 1395 07:02
Last Modified:22 May 1399 07:10

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