سمیت لیتیم بر روی میتوکندری ها و کاردیومیوسایت هاایزوله: یک توجیه برای اثرات زیان آور سمیت قلبی

سلیمی, احمد and غلامی فر, احسان and ناصر زاده, پروانه and حسینی, میر جمال and پوراحمد, جلال (1395) سمیت لیتیم بر روی میتوکندری ها و کاردیومیوسایت هاایزوله: یک توجیه برای اثرات زیان آور سمیت قلبی. Journal of Biochemical and Molecular Toxicology ــ 31 (2). pp. 232-241. شاپا 0461-1099


Official URL: http://onlinelibrary.wiley.com/doi/10.1002/jbt.218...


Toxicity of lithium on isolated heart mitochondria and cardiomyocyte: A justification for its cardiotoxic adverse effect

English Abstract

Mitochondria play an important role in myocardial tissue homeostasis; therefore, deterioration in mitochondrial function will eventually lead to cardiomyocyte and endothelial cell death and consequently cardiovascular dysfunction. Lithium (Li+) is an effective drug for bipolar disorder with known cardiotoxic side effects. This study was designed to investigate the effects of Li+ on mitochondria and cardiomyocytes isolated from the heart of Wistar rat. Results revealed that Li+ induced a concentration- and time-dependent rise in mitochondrial ROS formation, inhibition of respiratory complexes (II), mitochondrial membrane potential (MMP) collapse, mitochondrial swelling, and cytochrome c release in rat heart mitochondria and also induced Caspase 3 activation through mitochondrial pathway, decline of ATP and lipid peroxidation in rat cardiomyocytes. These results indicate that the cardiotoxic effects of Li+ were initiated from mitochondrial dysfunction and oxidative stress, which finally ends in cytochrome c release and cell death signaling heart cardiomyocytes.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :احمد سلیمی
نویسنده :احسان غلامی فر
نویسنده :پروانه ناصر زاده
نویسنده :میر جمال حسینی
نویسنده مسئول :جلال پوراحمد
Additional Information:IF: 1.837 Indexed in: ISI, Scopus, PubMed/Medline, Embase
کلیدواژه ها (انگلیسی):Lithium, cardiotoxicity,mitochondrial dysfunction, apoptosis
Subjects:QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:7814
Deposited By: Dr Ahmad Salimi
Deposited On:20 Jun 1395 11:06
Last Modified:25 Jan 1401 08:35

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