سیگار و سرطان معده (پروژه آنالیز تجمیعی سرطان معده)

Praud, Delphine and Matteo, Rota and Pelucchi, Claudio and Bertuccio, Paola and Rosso, Tiziana and Galeone, Carlotta and Zhang, Zuo-Feng and Matsuo, Keitaro and Ito, Hidemi and Hu, Jinfu and Johnson, Kenneth C and Yu, Guo-Pei and Palli, Domenico and Ferraroni, Monica and Muscat, Joshua and Lunet, Nuno and Peleteiro, Bárbara and ملک زاده, رضا and Ye, Weimin and Song, Huan and Zaridze, David and Maximovitch, Dmitry and Aragonés, Nuria and Castaño-Vinyals, Gemm and Vioque, Jesus and Navarrete-Muñoz, Eva M and پاک سرشت, محمدرضا and پورفرضی, فرهاد and Wolk, Alicja and Orsini, Nicola and Bellavia, Andrea and Håkansson, Niclas and Mu, Lina and Pastorino, Roberta and Kurtz, Robert C and درخشان, محمدحسین and Lagiou, Areti and Lagiou, Pagona and Boffetta, Paolo and Boccia, Stefania and Negri, Eva and La Vecchia, Carlo (1396) سیگار و سرطان معده (پروژه آنالیز تجمیعی سرطان معده). European Journal of Cancer Prevention ــ 27 (2). pp. 124-133. شاپا 8278-0959

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Official URL: https://journals.lww.com/eurjcancerprev/Abstract/2...


Cigarette smoking and gastric cancer in the Stomach Cancer Pooling Project (StoP)

English Abstract

Tobacco smoking is a known cause of gastric cancer, but several aspects of the association remain imprecisely quantified. We examined the relation between cigarette smoking and the risk of gastric cancer using a uniquely large dataset of 23 epidemiological studies within the 'Stomach cancer Pooling (StoP) Project', including 10 290 cases and 26 145 controls. We estimated summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study-specific ORs using random-effects models. Compared with never smokers, the ORs were 1.20 (95% CI: 1.09-1.32) for ever, 1.12 (95% CI: 0.99-1.27) for former, and 1.25 (95% CI: 1.11-1.40) for current cigarette smokers. Among current smokers, the risk increased with number of cigarettes per day to reach an OR of 1.32 (95% CI: 1.10-1.58) for smokers of more than 20 cigarettes per day. The risk increased with duration of smoking, to reach an OR of 1.33 (95% CI: 1.14-1.54) for more than 40 years of smoking and decreased with increasing time since stopping cigarette smoking (P for trend<0.01) and became similar to that of never smokers 10 years after stopping. Risks were somewhat higher for cardia than noncardia gastric cancer. Risks were similar when considering only studies with information on Helicobacter pylori infection and comparing all cases to H. pylori+ controls only. This study provides the most precise estimate of the detrimental effect of cigarette smoking on the risk of gastric cancer on the basis of individual data, including the relationship with dose and duration, and the decrease in risk following stopping smoking.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :Delphine Praud
نویسنده :فرهاد پورفرضی
Additional Information:Impact Factor (2016) 2.556 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, Chemical Abstracts, Google Scholar
کلیدواژه ها (انگلیسی):consortium; risk factors; pooled analysis; stomach neoplasms; tobacco smoking.
Subjects:WI Digestive System
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
ID Code:7826
Deposited By: Dr Farhad Pourfarzi
Deposited On:20 Jun 1395 11:07
Last Modified:12 Mar 1397 09:08

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