title

گزارش یه مورد نازوفارنژیال کارسینوما

فتحی, افشین and امانی, فیروز and داوودی, محمد and بهادرام, سارا and بهادرام, محمد (1395) گزارش یه مورد نازوفارنژیال کارسینوما. Iranian Journal of Cancer Prevention ــ 9 (4). pp. 1-4. شاپا 2008-2398

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Title

A Rare Presentation of Primary Nasopharyngeal Carcinoma NPC in Mediastinum

English Abstract

Introduction: Nasopharyngeal carcinoma among the children has been rare accounting for only 1% of all pediatric malignancies. Both genetic and environmental factors have contributed to the development of nasopharyngeal carcinoma. Among the children there was a higher rate of undifferentiated histology. The mean age of nasopharyngeal carcinoma diagnosis has been 11 years old age; and the most common site was nasopharynx. Palpable lymphadenopathy, dysphasia and neural defect were common associated signs. Case Presentation: A 15-year-old boy has presented with a mass that located near by the heart in the left side of mediastinum with invasion to anterior mediastinum from two years ago. In biopsy, nasopharyngeal carcinoma, non-keratinizing type, has diagnosed while there was no involvement of nasopharyngeal region. Patient has treated by 70 Gy (2.0 Gy/fraction) radiotherapy plus concomitant chemotherapy with base of docetaxel. But the mass had no regression. Then, the patient has treated with Cisplatin 100 mg/m2 IV on days 1, 22, and 43 with radiation, then cisplatin 80 mg/m2 IV on day 1 plus fluorouracil (5-FU) 1000 mg/m2/day by continuous IV infusion on days 1 - 4 every 4wk for 3 cycles and after remission interferon beta has added to treatment for 6 months duration as a maintenance therapy. After 1 year follow up; the patient was in complete remission. In the course of therapy, only hypothyroidism has occurred. Conclusions: Nasopharyngeal carcinoma in childhood, without nasopharyngeal involvement, initially could be detected in other sites such as pericardium. Also good results could be respected by cisplatin and 5-fluorouracil based neoadjuvant chemotherapy before radiotherapy plus interferon beta as a maintenance therapy in childhood aggressive nasopharyngeal carcinoma.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :افشین فتحی
نویسنده :فیروز امانی
نویسنده مسئول :محمد بهادرام
Additional Information:Indexed in: PubMed/PMC, Magiran
کلیدواژه ها (انگلیسی):Nasopharyngeal Carcinoma, Radiotherapy Resistant, Neoadjuvant Chemotherapy, Interferon
Subjects:WS Pediatrics
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
Faculty of Medicine > Department of Basic Sciences > Department of Vital Statistics
ID Code:7845
Deposited By: Dr Firouz Amani
Deposited On:27 Jun 1395 12:04
Last Modified:21 Feb 1399 16:43

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