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بررسی سطح خونی و بزاقی آنتی اکسیدانت، فاکتور رشد اپیدرمی و نیتریک اکساید در بیماران دیابتی وابسته به انسولین

مصطفی لو, سارا and آستانه ای, فاطمه and افشاری, مژگان and مجتهدی, علیرضا and زمانی, محمد جعفر and لاریجانی, باقر and عبدالهی, محمد (1388) بررسی سطح خونی و بزاقی آنتی اکسیدانت، فاکتور رشد اپیدرمی و نیتریک اکساید در بیماران دیابتی وابسته به انسولین. در: 2nd International Conference on Drug Discovery and Therapy, Feb 1-4 , 2010, ِDubai - Emirat.

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Title

Total antioxidant capacity and levels of epidermal growth factor and nitric oxide in blood and saliva of insulin-dependent diabetic patients

English Abstract

The aim of this study was to examine how type 1 diabetic patients have altered levels of lipid peroxidation, antioxidant defense, NO and EGF in their plasma and saliva. We tested the differences in lipid peroxidation level, antioxidant power, and concentrations of epidermal growth factor (EGF) and nitric oxide (NO) in saliva and blood of type 1 diabetic subjects in comparison to healthy control subjects. Methods: Nineteen subjects with type 1 diabetes mellitus and 19 healthy age- and sexmatched control subjects were included in the study. Blood and saliva samples were obtained and analyzed for thiobarbituric reactive substances (TBARS) as a marker of lipid peroxidation, ferric reducing ability (total antioxidant power), EGF and NO levels. Results: TBARS levels did not show a significant difference between the two groups. Analysis of antioxidant power revealed that saliva and plasma of diabetic patients had more antioxidant power (p <0.01) than the healthy control population (107 ± 10.35 vs. 11.14 ± 4.66 and 192 ± 12.3 vs. 142 ±15.2 mmol/L, respectively). Concentration of EGF was increased (p<0.01) in saliva whereas it was reduced (p <0.01) in plasma of diabetic patients in comparison to those of healthy subjects (2423 ± 322 vs. 1513 ± 341 and 125 ±14 vs. 346 ± 60 pg/mL, respectively). NO level increased in both saliva and plasma of diabetic patients in comparison to those of healthy subjects (46.61 ± 7 vs. 72.89 ± 13 and 62.11 ± 4.6 vs. 76.25 ± 5 μmol/L, respectively). Blood HbA1c (%) of patients was significantly higher than that of controls (8.3 ± 0.32 vs. 5.4 ± 0.24, p <0.01). Conclusions. Existence of increased total antioxidant power in the presence of normal lipid peroxidation in plasma and saliva of type 1 diabetic patients indicates the existence of oxidative stress. Increased salivary EGF and NO levels in association with elevated TAOP is interesting and should be further studied.

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده اول :سارا مصطفی لو
کلیدواژه ها (انگلیسی):Diabetes, Antioxidant, Nitric oxide, epidermal growth factor
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:7886
Deposited By: Dr Sara Mostafalou
Deposited On:11 Aug 1395 11:33
Last Modified:11 Aug 1395 11:33

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