اثرات تاموکسیفن روی جنبه های مورفولوژی و فراساختار هیپوکمپ در حال تکامل موش صحرایی

نوبخت, ملیحه and نجف زاده, نوروز and کردستانی شرق, بهاره (1388) اثرات تاموکسیفن روی جنبه های مورفولوژی و فراساختار هیپوکمپ در حال تکامل موش صحرایی. Iranian Biomedical Journal ــ 13 (4). pp. 171-177. شاپا 1028-852X

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Effects of Tamoxifen on Morphological and Ultrastructural Aspects of Developing Hippocampus of Rat

English Abstract

Background: Tamoxifen treatment induced cell death in the hippocampus formation of the prenatal and postnatal rat. The present study delineates the effect of tamoxifen on developing hippocampus in prenatal, postnatal and full term neonate rats received certain doses of the partial antagonist tamoxifen. Methods: After perfusion and fixation, the brains were removed and processed for light and electron microscopy. The morphology, ultrastructure and the density of the neurons in different ages (E22, P1, P7 and P21) and in different areas of developing hippocampus including cornu ammonis (CA1 and CA3), dentate gyrus and subiculum were studied. Results: These findings showed that in tamoxifen-treated groups, the cell number of pyramidal neurons of CA1 and subiculum significantly decreased comparing to control groups in E22, P1 and P7 but not in third weeks. The mitochondria of the above mentioned groups also showed a dilated feature with less cristae than control group and most of them were greatly enlarged and swollen into spherical shapes rather than the normal ovoid or rod shape. Conclusion: The present study shows that prenatal exposure to tamoxifen alters neurogenesis in developing rat hippocampus. These results demonstrated the nonneuroprotective roles of tamoxifen

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :ملیحه نوبخت
Additional Information:IBJ is indexing: 1- PubMed/MEDLINE, Index Medicus, 2-EMBASE, BIOBASE, Chemical Abstracts, Scopus,Islamic World Science Citation Database (ISC , Biosis, 3- ExtraMED-Cambridge Scientific Abstracts, CAB Abstract International, Index Copernicus, Directory of Open Access Journals (DOAJ), Index Medicus for the WHO Eastern Mediteranean Region (IMEMR),
Uncontrolled Keywords:هیپوکمپ در حال تکامل ، تاموکسیفن ، فراساختار
کلیدواژه ها (انگلیسی):Developing hippocampus , Tamoxifen , Ultrastructure
Subjects:QV pharmacology
QS Human Anatomy
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Anatomy
ID Code:794
Deposited By: Dr Nowruz Najafzadeh
Deposited On:04 Nov 1388 16:53
Last Modified:11 Jun 1393 06:07

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