نقش رادیکال های فعال در پیشرفت و درمان سرطان

پوراحمد, جلال and سلیمی, احمد and صیدی, عنایت اله (1395) نقش رادیکال های فعال در پیشرفت و درمان سرطان. در: Free Radicals and Diseases. InTech, Croatia, pp. 347-362. شابک 978-953-51-2746-8

Text - Published Version


Role of Oxygen Free Radicals in Cancer Development and Treatment

English Abstract

It is well known that species derived from oxygen are cytotoxic and are involved in the etiology of cancer. Several carcinogens during metabolism exert their effect by producing reactive oxygen species (ROS). One of the consequences of oxidative damage to cellular DNA is mutated. It plays a vital role in the process of carcinogenesis (especially in the initiation and progression). The alters, including rearrangement of DNA sequence, base modification DNA miscoding lesions, gene amplification and the activation of oncogenes, could be implicated in the initiation stage of several cancers. Mitochondrial changes in the cancer cells are well known and as a result are respiratory injured. Mitochondrial dysfunction could lead to a low coupling efficiency of the mitochondrial electron transport chain (mETC), raising electron leakage and increased ROS formation. It has been documented that by reducing and inactivation of antioxidant system, the oxidative stress (OS) in cancer cells is higher. Cancer cells exhibit a higher oxidative stress level compared to normal cells, rendering tumor cells more vulnerable to raise ROS levels. Therefore, increasing ROS levels through redox modulation can be a strategy to selectively kill cancer cells but not normal cells. A promising anti-cancer method named “oxidation therapy” has been developed by causing cytotoxic oxidative stress for cancer therapy. In this chapter, we described the role of ROS as a double-edged sword in cancer development and treatment.

Item Type:Book Section
زبان سند : انگلیسی
نویسنده اول :جلال پوراحمد
نویسنده :احمد سلیمی
نویسنده :عنایت اله صیدی
کلیدواژه ها (انگلیسی):Cancer, Reactive Oxygen Species, Oxidation Therapy, Mitochondria
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:7988
Deposited By: Dr Ahmad Salimi
Deposited On:07 Oct 1395 06:54
Last Modified:23 Mar 1397 11:52

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