مقایسه تاثیر کرم واژینال سیر، آویشن شیرازی و کلوتریمازول2% در بهبود واژینیت قارچی: یک کارآزمایی بالینی تصادفی کنترل شده

فرشباف خلیلی, عزیزه and محمدی قلعه بین, بهنام and شهنازی, مهناز and اصغری, سلطان and جوادزاده, یوسف and آذغانی, پیمان (1395) مقایسه تاثیر کرم واژینال سیر، آویشن شیرازی و کلوتریمازول2% در بهبود واژینیت قارچی: یک کارآزمایی بالینی تصادفی کنترل شده. Iranian Red Crescent Medical Journal ــ 18 (12). pp. 1-10. شاپا 2074-1812


Official URL: http://ircmj.com/en/articles/16723.html


Comparing the Effect of Garlic, Zataria multiflora and Clotrimazole Vaginal Cream 2% on Improvement of Fungal Vaginitis: A Randomized Controlled Trial

English Abstract

Abstract Background: Garlic and Zataria multiflora boiss (ZMB) are herbal medicines used traditionally in the treatment of infections, including candidal vaginitis. Objectives: This study aimed to examine the effect of garlic and ZMB vaginal cream 2%, in the treatment and recurrence of candidal vaginitis. Methods: This randomized, double-blinded clinical trial was conducted on240 married womenwith candidal vaginitis. The patients used 5 gr garlic, ZMBor clotrimazole vaginal cream 2% daily, for 7 days. Complaints of the patients, clinical observations and laboratory parameters were recorded before treatment, on days 7 and 30, after treatment. The data were analyzed by SPSS v. 21 through chi-square, Fisher, ANOVA with repeated measures, McNemar and Kruskal-Wallis tests. A P <0.05 was considered significant. Results: Before treatment, all patients had positive candidiasis fungi culture, in both groups (100%). The positive culture was 14.1%, 15.2%, 10.3%, respectively, on day 7 after treatment and 2.6%, 0%, 0% on day 30, after treatment with garlic, ZMB and clotrimazole, respectively (P < 0.001). No significant differences were observed between groups on days 7 (P = 0.69) and 30 (P = 0.21) after treatment, in culture results. There were no significant differences between groups, in terms of patient complaints and clinical observations before intervention, at days 7 and 30 after treatment (P > 0.05). Mean scores of candidal symptoms reduced significantly in all groups at on 7 and 30, after treatment (P < 0.001). Conclusions: Garlic and ZMB vaginal cream 2% can be used as an effective treatment option in cases of drug resistance and, also, by the people who are interested in treating with herbal medicines.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :عزیزه فرشباف خلیلی
نویسنده :بهنام محمدی قلعه بین
نویسنده :مهناز شهنازی
نویسنده مسئول :سلطان اصغری
نویسنده :یوسف جوادزاده
نویسنده :پیمان آذغانی
Additional Information:Impact Factor (2016) 0.865 Indexed in: ISI, Pubmed, Embase, Open-J-Gate, DOAJ, Index Copernicus,Google Scholar, ISC, MagIran, SID
کلیدواژه ها (انگلیسی):Vaginitis , Candidiasis , Garlic, Clotrimazole , Herbal Medicine
Subjects:QV pharmacology
QW Microbiology and Immunology
WP Gynecology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Parasitology
ID Code:7990
Deposited By: Dr Behnam Mohammadi Ghalebin
Deposited On:04 Sep 1395 08:14
Last Modified:02 Oct 1397 16:48

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