title

SC-01RalA در زیست شناسی و درمان MPNST در ارتباط با سلولهای بنیادی سرطان

Terai, Kaoru and Borrego-Diaz, Emma and Lovick, Darren and Salacz, Michael and رضایی مقدم, عادل and صنعتی, زهره and دولتخواه, رویا and پات راد, الهام and امانی, مجتبی and Peng, Warner and اسفندیاری, طوبی and Farassati, Faris (1394) SC-01RalA در زیست شناسی و درمان MPNST در ارتباط با سلولهای بنیادی سرطان. Neuro-oncology ــ 17 (S3). iii35-iii36. شاپا 1522-8517

[img]
Preview
Text
28kB

Official URL: https://academic.oup.com/neuro-oncology/article/17...


Title

SC-01RalA IN BIOLOGY AND THERAPY OF MPNST IN CORRELATION TO CANCER STEM CELLS

English Abstract

For the last 20 years, cellular biologists have been focusing on the role of Ras signaling pathway in neurofibromatosis 1(NF1) and its lethal derivation, malignant peripheral nerve sheath tumors (MPNST). While our team has worked on the influence of Ras pathway on responsiveness of MPNST cells to therapy, we introduced a novel cell signaling pathway down-stream of Ras, i.e. Ral pathway, as an important regulator of the biological features of MPNST with potentials for being targeted for treatment of this malignancy. We have also showed that RalA is overactivated in the cancer stem cell (CSC) fraction of MPNST tumors establishing this pathway to harbor potentials for targeting MPNST CSCs. In summary our preliminary data shed light on following facts: 1- RalA signaling pathway is overactivated in differentiated MPNST cells and human tissues. 2- RalA overactivation is a characteristic of MPNST cancer stem cells. 3- RalA inhibition hinders the malignant phenotype of MPNST cells. 4- Disruption of RalA signaling results in loss of viability and invasion of MPNST cells. In this presentation, we further evaluate the mechanism of RalA overactivation and in-vivo potentials of its inhibition as a therapeutic strategy for MPNST.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :Kaoru Terai
نویسنده :مجتبی امانی
نویسنده مسئول :Faris Farassati
Additional Information:IF: 10.091 Indexed in: ISI, PubMed/Medline, Scopus
کلیدواژه ها (انگلیسی):nerve sheath tumors, cancer stem cells
Subjects:QU Biochemistry
Divisions:School of Pharmacy > Department Biophysical
ID Code:8035
Deposited By: Dr Mojtaba Amani
Deposited On:13 Apr 1398 08:03
Last Modified:13 Apr 1398 08:03

Repository Staff Only: item control page

Document Downloads

More statistics for this item...