بررسی سطح اسیداوریک خون در زنان حامله در میانه حاملگی با وزن موقع تولد و مقاومت به انسولین

عنوان انگليسی

Mid-gestational serum uric acid concentration effect on neonate birth weight and insulin resistance in pregnant women

خلاصه انگلیسی

Objective: To investigate the relationship between mid‑gestational serum uric acid and birth weight in diabetic pregnant women with or without insulin resistance. Methods: In a prospective cohort study, fasting uric acid, blood glucose, and serum insulin were measured in 247 pregnant women between 20‑22 weeks of gestational period. Insulin resistance was estimated using the homeostasis model assessment‑insulin resistance (HOMA‑IR). Stratification analysis and independent t‑test was used to assess the association between uric acid and birth weights regarding to insulin resistance. Results: The means of the mid‑gestational serum uric acid concentrations were not significantly different in women with and without insulin resistance. But stratification analysis showed that there was a significant difference between uric acid concentration and macrosomic birth in diabetic women without insulin resistance. Conclusions: Higher mid – gestation serum uric acid concentration, even if it does not exceed the normal range, is accompanied by lower birth weight only in non‑insulin resistance women. Insulin resistance could have a negative confounding effect on hyperuriemia and birth weight. Key Words: Second trimester, hyperuricemia, homeostasis model assessment-insulin resistance , Metabolic syndrome

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