title

بررسی سطح اسیداوریک خون در زنان حامله در میانه حاملگی با وزن موقع تولد و مقاومت به انسولین

نصری, خدیجه and رضوی, مریم السادات and رضوان فر, محمدرضا and مشهدی, عصمت and چهری, علی and محمد بیگی, ابولفضل (1393) بررسی سطح اسیداوریک خون در زنان حامله در میانه حاملگی با وزن موقع تولد و مقاومت به انسولین. International Journal of Critical Illness and Injury Science ــ 5 (1). pp. 17-20. شاپا 2229-5151

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Title

Mid-gestational serum uric acid concentration effect on neonate birth weight and insulin resistance in pregnant women

English Abstract

Objective: To investigate the relationship between mid‑gestational serum uric acid and birth weight in diabetic pregnant women with or without insulin resistance. Methods: In a prospective cohort study, fasting uric acid, blood glucose, and serum insulin were measured in 247 pregnant women between 20‑22 weeks of gestational period. Insulin resistance was estimated using the homeostasis model assessment‑insulin resistance (HOMA‑IR). Stratification analysis and independent t‑test was used to assess the association between uric acid and birth weights regarding to insulin resistance. Results: The means of the mid‑gestational serum uric acid concentrations were not significantly different in women with and without insulin resistance. But stratification analysis showed that there was a significant difference between uric acid concentration and macrosomic birth in diabetic women without insulin resistance. Conclusions: Higher mid – gestation serum uric acid concentration, even if it does not exceed the normal range, is accompanied by lower birth weight only in non‑insulin resistance women. Insulin resistance could have a negative confounding effect on hyperuriemia and birth weight. Key Words: Second trimester, hyperuricemia, homeostasis model assessment-insulin resistance , Metabolic syndrome

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :خدیجه نصری
نویسنده :مریم السادات رضوی
نویسنده مسئول :محمدرضا رضوان فر
Additional Information:Indexed in: Pubmed, Index Copernicus, Indian Science Abstracts, Hinari, Infotrieve, Journal Guide, National Science Library, OpenJGate, ProQuest, Google Scholar
کلیدواژه ها (انگلیسی):Second trimester, hyperuricemia, homeostasis model assessment-insulin resistance , Metabolic syndrome
Subjects:W Health professions
WP Gynecology
Divisions:Faculty of Medicine > Department of Anesthesiology , Obstetrics & Gynecology
ID Code:8038
Deposited By: دکتر مریم السادات رضوی
Deposited On:06 Sep 1395 09:24
Last Modified:06 Sep 1395 09:24

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