بررسی اثر مکمل سلنیوم روی فاکتورهای التهابی و استرس اکسیداتیو در زنان مبتلا به PCO

رضوی, مریم السادات and جمیلیان, مهری and فخری کاشان, زهره and حیدر, زد and محسنی, ام and قندی, یاسر and باقریان, طیبه and عاصمی, ذات اله (1395) بررسی اثر مکمل سلنیوم روی فاکتورهای التهابی و استرس اکسیداتیو در زنان مبتلا به PCO. Hormone and Metabolic Research ــ 48 (3). pp. 185-190. شاپا 0018-5043


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Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome

English Abstract

Selenium supplementation could be effective on reproductive outcomes, biomarkers of inflammation, and oxidative stress among women with polycystic ovary syndrome (PCOS). The aim of the study was to determine the effects of selenium supplementation on reproductive outcomes, biomarkers of inflammation, and oxidative stress in PCOS patients. The present randomized double-blind, placebo-controlled trial was conducted on 64 women aged 18–40 years old with PCOS at the clinic affiliated to Ardabil University of Medical Sciences, Ardabil, Iran. The participants were randomly assigned to 2 groups receiving either 200 μg selenium daily (n=32) or placebo (n=32) for 8 weeks. Hormonal profiles, biomarkers of inflammation, and oxidative stress were measured and compared both before and after the treatment. After 8 weeks of intervention, pregnancy rate in the selenium group was higher than in the placebo group: 18.8 (6/32) vs. 3.1% (1/32), p=0.04. In addition, alopecia (40.6 vs. 9.4%, p=0.004) and acne (46.9 vs. 12.5 %, p=0.003) decreased following the consumption of selenium supplements compared with placebo. Additionally, patients who received selenium supplements had significantly decreased serum dehydroepiandrosterone (DHEA) levels (p=0.02), hirsutism (modified Ferriman–Gallwey scores) (p<0.001), serum high sensitivity C-reactive protein (hs-CRP) (p=0.02), and plasma malondialdehyde (MDA) levels (p=0.01) compared with placebo. We did not observe any significant effects of taking selenium supplements on other hormonal profiles, nitric oxide (NO), and other biomarkers of oxidative stress. Taken together, selenium supplementation for 8 weeks among PCOS women had beneficial effects on reproductive outcomes, DHEA, hs-CRP, and MDA levels.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :مریم السادات رضوی
نویسنده مسئول :ذات اله عاصمی
Additional Information:Impact Factor (2016) 2.268 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, Current Contents, EMBASE
کلیدواژه ها (انگلیسی):selenium - supplementation - polycystic ovary syndrome - reproductive outcomes - inflammation - oxidative stress
Subjects:WK Endocrine System
WP Gynecology
WQ Obstetrics
Divisions:Faculty of Medicine > Department of Anesthesiology , Obstetrics & Gynecology
ID Code:8040
Deposited By: دکتر مریم السادات رضوی
Deposited On:22 May 1397 10:59
Last Modified:15 Oct 1398 13:43

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