بررسی اثر امگا 3 در زنان باردار مبتلا به GDM

جمیلیان, مهری and صمیمی, منصوره and کلاهدوز, فریبا and خلجی, فرزانه and رضوی, مریم السادات and عاصمی, ذات اله (1394) بررسی اثر امگا 3 در زنان باردار مبتلا به GDM. Journal of Maternal-Fetal & Neonatal Medicine ــ online . pp. 669-676. شاپا 7058-1476

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Omega-3 fatty acid supplementation affects pregnancy outcomes in gestational diabetes: a randomized, double-blind, placebo-controlled trial

English Abstract

Objective: This study was designed to assess the effects of omega-3 fatty acid supplementation on inflammatory factors, biomarkers of oxidative stress, and pregnancy outcomes among pregnant women with gestational diabetes (GDM). Methods: This randomized, double-blind, placebo-controlled clinical trial was performed among 56 women with GDM. Subjects were randomly selected to receive either 1000mg omega-3 fatty acid supplements (containing 180mg eicosapentaenoic acid and 120mg docosahexanoic acid) (n¼27) or a placebo (n¼27) for 6 weeks. Fasting blood samples were taken at study baseline and after 6 weeks of intervention to quantify biochemical variables. Newborn’s weight, height, head circumference, Apgar score, and hyperbilirubinemia were determined. Results: At the end of the 6 weeks, taking omega-3 fatty acid significantly decreased serum high-sensitivity C-reactive protein (hs-CRP) (change from baseline: �245.1 ± 1570.5 versus + 913.9 ± 2329.4 ng/mL, p¼0.03) and plasma malondialdehyde (MDA) concentrations (�0.4 ± 1.3 versus + 0.6±2.3, p¼0.04) compared with the placebo. Supplementation with omega-3 had a low incidence of hyperbilirubinemiain newborns (7.7% versus 33.3%, p¼0.02) and decreased newborns’ hospitalization rate (7.7% versus 33.3%, p¼0.02). Conclusions: Taken together, omega-3 fatty acid supplementation in GDM women had beneficial effects on maternal serum hs-CRP, plasma MDA levels, incidence of newborn’s hyperbilirubinemia, and hospitalization.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :مهری جمیلیان
نویسنده :مریم السادات رضوی
نویسنده مسئول :ذات اله عاصمی
Additional Information:Impact Factor (2015) 1.674 Indexed in: ISI, Pubmed/ Medline/Index Medicus, Scopus, Chemical Abstracts, Current Contents/Clinical Medicine, Current Awareness in Biological Sciences
کلیدواژه ها (انگلیسی):Gestational diabetes, omega-3 fatty acid,pregnancy outcomes, pregnant women, supplementation
Subjects:WK Endocrine System
WP Gynecology
WQ Obstetrics
Divisions:Faculty of Medicine > Department of Anesthesiology , Obstetrics & Gynecology
ID Code:8042
Deposited By: Dr Maryamalsadat Razavi
Deposited On:19 Aug 1395 10:48
Last Modified:19 Aug 1395 10:48

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