بررسی پاسخ متابولیک به مکمل سلنیوم در زنان مبتلا به PCO

جمیلیان, مهری and رضوی, مریم السادات and فخری کاشان, زهره and قندی, یاسر and باقریان, طیبه and عاصمی, ذات اله (1394) بررسی پاسخ متابولیک به مکمل سلنیوم در زنان مبتلا به PCO. Clinical Endocrinology ــ 82 (6). pp. 885-891. شاپا 1365-2265

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Official URL: http://onlinelibrary.wiley.com/journal/10.1111/(IS...


Metabolic response to selenium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial

English Abstract

Objective We are aware of no study examining the effects of selenium supplementation on metabolic profiles of patients with polycystic ovary syndrome (PCOS). This study was conducted to evaluate the effects of selenium supplementation on glucose homeostasis parameters and lipid concentrations in women with PCOS. Design, patients and measurements This randomized, double- blind, placebo-controlled trial was conducted among 70 women diagnosed with PCOS and aged 18–40 years old. Participants were randomly divided into two groups to receive 200 lg per day selenium supplements (N = 35) or placebo (N = 35) for 8 weeks. Fasting blood samples were taken at baseline and after 8 weeks intervention to quantify glucose, insulin and lipid concentrations. Results After 8 weeks of intervention, subjects who received selenium supplements had significantly decreased serum insulin levels (�29�83 � 47�29 vs +9�07 � 77�12 pmol/l, P = 0�013), homeostasis model of assessment-insulin resistance (HOMA-IR) (�1�15 � 1�81 vs +0�42 � 3�09, P = 0�011), homeostatic model assessment-beta-cell function (HOMA-B) (�19�06 � 30�95 vs +4�55 � 47�99, P = 0�017) and increased quantitative insulin sensitivity check index (QUICKI) (+0�03 � 0�04 vs +0�0009 � 0�05, P = 0�032) compared with placebo. In addition, supplementation with selenium resulted in a significant reduction in serum triglycerides (�0�14 � 0�55 vs +0�11 � 0�30 mmol/l, P = 0�025) and VLDL-C concentrations (�0�03 � 0�11 vs +0�02 � 0�06 mmol/l, P = 0�025) compared with placebo. Conclusions In conclusion, 200 microgram per day selenium supplementation for 8 weeks among PCOS women had beneficial effects on insulin metabolism parameters, triglycerides and VLDL-C levels; however, it did not affect FPG and other lipid profiles.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :مهری جمیلیان
نویسنده :مریم السادات رضوی
نویسنده مسئول :ذات اله عاصمی
Additional Information:Impact Factor(2015) 3.487 Indexed in: ISI, PubMed/Medline/Index Medicus, Abstracts in Anthropology (Sage) , Abstracts on Hygiene & Communicable Diseases (CABI) , BIOBASE: Current Awareness in Biological Sciences (Elsevier) ,Biological Abstracts, CAB Abstracts, Embase (Elsevier) , Nutrition Abstracts & Reviews Series A: Human & Experimental (CABI)
Subjects:WP Gynecology
WQ Obstetrics
Divisions:Faculty of Medicine > Department of Anesthesiology , Obstetrics & Gynecology
ID Code:8043
Deposited By: Dr Maryamalsadat Razavi
Deposited On:29 Aug 1395 11:35
Last Modified:04 May 1397 11:23

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